Clinicopathological Characteristics of Young Patients with Pancreatic Cancer

Hidetoshi Eguchi, Hiroki Yamaue, Michiaki Unno, Masamichi Mizuma, Shin Hamada, Hisato Igarashi, Tamotsu Kuroki, Sohei Satoi, Yasuhiro Shimizu, Masaji Tani, Satoshi Tanno, Yoshiki Hirooka, Tsutomu Fujii, Atsushi Masamune, Kazuhiro Mizumoto, Takao Itoi, Shinichi Egawa, Yuzo Kodama, Masao Tanaka, Tooru Shimosegawa

Research output: Contribution to journalArticle

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Abstract

Objectives The aim of this study was to determine the characteristics of patients with pancreatic ductal adenocarcinoma younger than 40 years. Methods Data from the Japan Pancreas Society's nationwide Pancreatic Cancer Registry were analyzed retrospectively. Clinicopathological characteristics were compared in patients who were grouped according to age, namely, younger than 40 years versus 40 years and older. Results Of the 36 145 patients in the database, the younger group included 526 (1.5%) patients. A family history of pancreatic cancer was not more frequent in the younger group. The frequency of Union Internationale Contre le Cancer T4 and M1 were both significantly higher in younger patients, resulting in a higher percentage of patients with Union Internationale Contre le Cancer stage IV. Pancreatectomy was performed less frequently in the younger group, and R0 resection was also less frequent. The overall survival rate was significantly better in the older group, whereas in surgically resected patients, the overall survival and recurrence-free survival rates were not different between the 2 groups. Conclusions Younger patients with pancreatic adenocarcinoma were more often diagnosed at advanced stages, and the overall survival rate was worse than that in older patients. Family genetic background and the prognoses of patients who underwent surgery were similar between the 2 groups.

Original languageEnglish
Pages (from-to)1411-1417
Number of pages7
JournalPancreas
Volume45
Issue number10
DOIs
Publication statusPublished - Nov 1 2016

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Pancreatic Neoplasms
Survival Rate
Adenocarcinoma
Pancreatectomy
Registries
Pancreas
Neoplasms
Japan
Databases
Recurrence
Survival

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

Cite this

Eguchi, H., Yamaue, H., Unno, M., Mizuma, M., Hamada, S., Igarashi, H., ... Shimosegawa, T. (2016). Clinicopathological Characteristics of Young Patients with Pancreatic Cancer. Pancreas, 45(10), 1411-1417. https://doi.org/10.1097/MPA.0000000000000636

Clinicopathological Characteristics of Young Patients with Pancreatic Cancer. / Eguchi, Hidetoshi; Yamaue, Hiroki; Unno, Michiaki; Mizuma, Masamichi; Hamada, Shin; Igarashi, Hisato; Kuroki, Tamotsu; Satoi, Sohei; Shimizu, Yasuhiro; Tani, Masaji; Tanno, Satoshi; Hirooka, Yoshiki; Fujii, Tsutomu; Masamune, Atsushi; Mizumoto, Kazuhiro; Itoi, Takao; Egawa, Shinichi; Kodama, Yuzo; Tanaka, Masao; Shimosegawa, Tooru.

In: Pancreas, Vol. 45, No. 10, 01.11.2016, p. 1411-1417.

Research output: Contribution to journalArticle

Eguchi, H, Yamaue, H, Unno, M, Mizuma, M, Hamada, S, Igarashi, H, Kuroki, T, Satoi, S, Shimizu, Y, Tani, M, Tanno, S, Hirooka, Y, Fujii, T, Masamune, A, Mizumoto, K, Itoi, T, Egawa, S, Kodama, Y, Tanaka, M & Shimosegawa, T 2016, 'Clinicopathological Characteristics of Young Patients with Pancreatic Cancer', Pancreas, vol. 45, no. 10, pp. 1411-1417. https://doi.org/10.1097/MPA.0000000000000636
Eguchi H, Yamaue H, Unno M, Mizuma M, Hamada S, Igarashi H et al. Clinicopathological Characteristics of Young Patients with Pancreatic Cancer. Pancreas. 2016 Nov 1;45(10):1411-1417. https://doi.org/10.1097/MPA.0000000000000636
Eguchi, Hidetoshi ; Yamaue, Hiroki ; Unno, Michiaki ; Mizuma, Masamichi ; Hamada, Shin ; Igarashi, Hisato ; Kuroki, Tamotsu ; Satoi, Sohei ; Shimizu, Yasuhiro ; Tani, Masaji ; Tanno, Satoshi ; Hirooka, Yoshiki ; Fujii, Tsutomu ; Masamune, Atsushi ; Mizumoto, Kazuhiro ; Itoi, Takao ; Egawa, Shinichi ; Kodama, Yuzo ; Tanaka, Masao ; Shimosegawa, Tooru. / Clinicopathological Characteristics of Young Patients with Pancreatic Cancer. In: Pancreas. 2016 ; Vol. 45, No. 10. pp. 1411-1417.
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AU - Yamaue, Hiroki

AU - Unno, Michiaki

AU - Mizuma, Masamichi

AU - Hamada, Shin

AU - Igarashi, Hisato

AU - Kuroki, Tamotsu

AU - Satoi, Sohei

AU - Shimizu, Yasuhiro

AU - Tani, Masaji

AU - Tanno, Satoshi

AU - Hirooka, Yoshiki

AU - Fujii, Tsutomu

AU - Masamune, Atsushi

AU - Mizumoto, Kazuhiro

AU - Itoi, Takao

AU - Egawa, Shinichi

AU - Kodama, Yuzo

AU - Tanaka, Masao

AU - Shimosegawa, Tooru

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N2 - Objectives The aim of this study was to determine the characteristics of patients with pancreatic ductal adenocarcinoma younger than 40 years. Methods Data from the Japan Pancreas Society's nationwide Pancreatic Cancer Registry were analyzed retrospectively. Clinicopathological characteristics were compared in patients who were grouped according to age, namely, younger than 40 years versus 40 years and older. Results Of the 36 145 patients in the database, the younger group included 526 (1.5%) patients. A family history of pancreatic cancer was not more frequent in the younger group. The frequency of Union Internationale Contre le Cancer T4 and M1 were both significantly higher in younger patients, resulting in a higher percentage of patients with Union Internationale Contre le Cancer stage IV. Pancreatectomy was performed less frequently in the younger group, and R0 resection was also less frequent. The overall survival rate was significantly better in the older group, whereas in surgically resected patients, the overall survival and recurrence-free survival rates were not different between the 2 groups. Conclusions Younger patients with pancreatic adenocarcinoma were more often diagnosed at advanced stages, and the overall survival rate was worse than that in older patients. Family genetic background and the prognoses of patients who underwent surgery were similar between the 2 groups.

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