Clinicopathological features and prognosis of mucinous cystic neoplasm with ovarian-type stroma: A multi-institutional study of the Japan pancreas society

Kenji Yamao, Akio Yanagisawa, Kuniyuki Takahashi, Wataru Kimura, Ryuichiro Doi, Noriyoshi Fukushima, Nobuyuki Ohike, Michio Shimizu, Takashi Hatori, Bunsei Nobukawa, Michio Hifumi, Yuji Kobayashi, Kosuke Tobita, Satoshi Tanno, Masanori Sugiyama, Yoshihiro Miyasaka, Toshio Nakagohri, Taketo Yamaguchi, Keiji Hanada, Hideki AbeMinoru Tada, Naotaka Fujita, Masao Tanaka

Research output: Contribution to journalArticle

133 Citations (Scopus)

Abstract

Objective: The aim of this study was to elucidate the clinicopathological features and prognosis of mucinous cystic neoplasms (MCNs). MATERIALS AND Methods: We performed a multi-institutional, retrospective study on a collected series of patients with MCN pathologically defined by ovarian-type stroma. Clinicopathological features and prognosis were investigated. RESULT: Mucinous cystic neoplasm was confirmed in 156 cases, including 129 adenomas (82.7%) and 21 noninvasive (13.4%) and 6 invasive carcinomas (3.9%). Patients with MCN were exclusively women (98.1%) with the mean age of 48.1 years. All but 1 MCN were in the pancreatic body/tail region with a mean size of 65.3 mm. Communication between the cyst and the pancreatic duct was found in 18.1%. The 3-, 5-, and 10-year survival rates were 97.6%, 96.6%, and 96.6%, respectively. A significant difference in the survival rates was observed between adenomas and carcinomas and between minimally invasive carcinomas and invasive carcinomas. Cyst diameter and presence of mural nodule were predictive of malignant MCN. Conclusions: Mucinous cystic neoplasm is a rare but distinctive pancreatic cystic neoplasm with a favorable overall prognosis. All MCNs should be resected to prevent malignant changes but can be observed for an appropriate time when the lesion is small without the presence of mural nodules.

Original languageEnglish
Pages (from-to)67-71
Number of pages5
JournalPancreas
Volume40
Issue number1
DOIs
Publication statusPublished - Jan 1 2011

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Ovarian Neoplasms
Pancreas
Japan
Neoplasms
Carcinoma
Adenoma
Cysts
Survival Rate
Body Regions
Pancreatic Ducts
Pancreatic Neoplasms
Retrospective Studies
Communication

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

Cite this

Clinicopathological features and prognosis of mucinous cystic neoplasm with ovarian-type stroma : A multi-institutional study of the Japan pancreas society. / Yamao, Kenji; Yanagisawa, Akio; Takahashi, Kuniyuki; Kimura, Wataru; Doi, Ryuichiro; Fukushima, Noriyoshi; Ohike, Nobuyuki; Shimizu, Michio; Hatori, Takashi; Nobukawa, Bunsei; Hifumi, Michio; Kobayashi, Yuji; Tobita, Kosuke; Tanno, Satoshi; Sugiyama, Masanori; Miyasaka, Yoshihiro; Nakagohri, Toshio; Yamaguchi, Taketo; Hanada, Keiji; Abe, Hideki; Tada, Minoru; Fujita, Naotaka; Tanaka, Masao.

In: Pancreas, Vol. 40, No. 1, 01.01.2011, p. 67-71.

Research output: Contribution to journalArticle

Yamao, K, Yanagisawa, A, Takahashi, K, Kimura, W, Doi, R, Fukushima, N, Ohike, N, Shimizu, M, Hatori, T, Nobukawa, B, Hifumi, M, Kobayashi, Y, Tobita, K, Tanno, S, Sugiyama, M, Miyasaka, Y, Nakagohri, T, Yamaguchi, T, Hanada, K, Abe, H, Tada, M, Fujita, N & Tanaka, M 2011, 'Clinicopathological features and prognosis of mucinous cystic neoplasm with ovarian-type stroma: A multi-institutional study of the Japan pancreas society', Pancreas, vol. 40, no. 1, pp. 67-71. https://doi.org/10.1097/MPA.0b013e3181f749d3
Yamao, Kenji ; Yanagisawa, Akio ; Takahashi, Kuniyuki ; Kimura, Wataru ; Doi, Ryuichiro ; Fukushima, Noriyoshi ; Ohike, Nobuyuki ; Shimizu, Michio ; Hatori, Takashi ; Nobukawa, Bunsei ; Hifumi, Michio ; Kobayashi, Yuji ; Tobita, Kosuke ; Tanno, Satoshi ; Sugiyama, Masanori ; Miyasaka, Yoshihiro ; Nakagohri, Toshio ; Yamaguchi, Taketo ; Hanada, Keiji ; Abe, Hideki ; Tada, Minoru ; Fujita, Naotaka ; Tanaka, Masao. / Clinicopathological features and prognosis of mucinous cystic neoplasm with ovarian-type stroma : A multi-institutional study of the Japan pancreas society. In: Pancreas. 2011 ; Vol. 40, No. 1. pp. 67-71.
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abstract = "Objective: The aim of this study was to elucidate the clinicopathological features and prognosis of mucinous cystic neoplasms (MCNs). MATERIALS AND Methods: We performed a multi-institutional, retrospective study on a collected series of patients with MCN pathologically defined by ovarian-type stroma. Clinicopathological features and prognosis were investigated. RESULT: Mucinous cystic neoplasm was confirmed in 156 cases, including 129 adenomas (82.7{\%}) and 21 noninvasive (13.4{\%}) and 6 invasive carcinomas (3.9{\%}). Patients with MCN were exclusively women (98.1{\%}) with the mean age of 48.1 years. All but 1 MCN were in the pancreatic body/tail region with a mean size of 65.3 mm. Communication between the cyst and the pancreatic duct was found in 18.1{\%}. The 3-, 5-, and 10-year survival rates were 97.6{\%}, 96.6{\%}, and 96.6{\%}, respectively. A significant difference in the survival rates was observed between adenomas and carcinomas and between minimally invasive carcinomas and invasive carcinomas. Cyst diameter and presence of mural nodule were predictive of malignant MCN. Conclusions: Mucinous cystic neoplasm is a rare but distinctive pancreatic cystic neoplasm with a favorable overall prognosis. All MCNs should be resected to prevent malignant changes but can be observed for an appropriate time when the lesion is small without the presence of mural nodules.",
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T1 - Clinicopathological features and prognosis of mucinous cystic neoplasm with ovarian-type stroma

T2 - A multi-institutional study of the Japan pancreas society

AU - Yamao, Kenji

AU - Yanagisawa, Akio

AU - Takahashi, Kuniyuki

AU - Kimura, Wataru

AU - Doi, Ryuichiro

AU - Fukushima, Noriyoshi

AU - Ohike, Nobuyuki

AU - Shimizu, Michio

AU - Hatori, Takashi

AU - Nobukawa, Bunsei

AU - Hifumi, Michio

AU - Kobayashi, Yuji

AU - Tobita, Kosuke

AU - Tanno, Satoshi

AU - Sugiyama, Masanori

AU - Miyasaka, Yoshihiro

AU - Nakagohri, Toshio

AU - Yamaguchi, Taketo

AU - Hanada, Keiji

AU - Abe, Hideki

AU - Tada, Minoru

AU - Fujita, Naotaka

AU - Tanaka, Masao

PY - 2011/1/1

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N2 - Objective: The aim of this study was to elucidate the clinicopathological features and prognosis of mucinous cystic neoplasms (MCNs). MATERIALS AND Methods: We performed a multi-institutional, retrospective study on a collected series of patients with MCN pathologically defined by ovarian-type stroma. Clinicopathological features and prognosis were investigated. RESULT: Mucinous cystic neoplasm was confirmed in 156 cases, including 129 adenomas (82.7%) and 21 noninvasive (13.4%) and 6 invasive carcinomas (3.9%). Patients with MCN were exclusively women (98.1%) with the mean age of 48.1 years. All but 1 MCN were in the pancreatic body/tail region with a mean size of 65.3 mm. Communication between the cyst and the pancreatic duct was found in 18.1%. The 3-, 5-, and 10-year survival rates were 97.6%, 96.6%, and 96.6%, respectively. A significant difference in the survival rates was observed between adenomas and carcinomas and between minimally invasive carcinomas and invasive carcinomas. Cyst diameter and presence of mural nodule were predictive of malignant MCN. Conclusions: Mucinous cystic neoplasm is a rare but distinctive pancreatic cystic neoplasm with a favorable overall prognosis. All MCNs should be resected to prevent malignant changes but can be observed for an appropriate time when the lesion is small without the presence of mural nodules.

AB - Objective: The aim of this study was to elucidate the clinicopathological features and prognosis of mucinous cystic neoplasms (MCNs). MATERIALS AND Methods: We performed a multi-institutional, retrospective study on a collected series of patients with MCN pathologically defined by ovarian-type stroma. Clinicopathological features and prognosis were investigated. RESULT: Mucinous cystic neoplasm was confirmed in 156 cases, including 129 adenomas (82.7%) and 21 noninvasive (13.4%) and 6 invasive carcinomas (3.9%). Patients with MCN were exclusively women (98.1%) with the mean age of 48.1 years. All but 1 MCN were in the pancreatic body/tail region with a mean size of 65.3 mm. Communication between the cyst and the pancreatic duct was found in 18.1%. The 3-, 5-, and 10-year survival rates were 97.6%, 96.6%, and 96.6%, respectively. A significant difference in the survival rates was observed between adenomas and carcinomas and between minimally invasive carcinomas and invasive carcinomas. Cyst diameter and presence of mural nodule were predictive of malignant MCN. Conclusions: Mucinous cystic neoplasm is a rare but distinctive pancreatic cystic neoplasm with a favorable overall prognosis. All MCNs should be resected to prevent malignant changes but can be observed for an appropriate time when the lesion is small without the presence of mural nodules.

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