Clinicopathological features of long-term survivors for advanced biliary tract cancer and impact of the number of lymph nodes involved

Shogo Kobayashi, Hiroaki Nagano, Shigeru Marubashi, Koichi Kawamoto, Hiroshi Wada, Hidetoshi Eguchi, Masahiro Tanemura, Koji Umeshita, Yuichiro Doki, Masaki Mori

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Abstract

Background & aim: To investigate the characteristics of long-term survivors after surgery for advanced biliary tract cancer (BTC), especially those with local invasion and/or lymph node involvement. Methods: We analyzed the features of long-term survivors using a prospectively collected database and verified the results using recent patients' data which have been well-described, especially in relation to lymph node dissection and metastasis. We used classification by the Japanese Society of Biliary Surgery (JSBS). Results: Among 170 patients with advanced BTC (Stage III or IV in JSBS), 25 (10 bile duct cancer, 9 gall bladder cancer, and 6 cancer of the papilla of Vater) survived for more than 5 years. Twenty-four patients had undergone fCurA/B (R0) surgery in these 25 patients. In comparison with the patients who did not survive for 5 years, the long-term survivors had fewer metastatic lymph nodes, that is, up to three (p = 0.0028). In regard to the impact of lymph node metastasis, the prognostic factor was the number of lymph nodes (3-year overall survival, 0 or 1: 68.1% vs >2: 40.0%, p = 0.0304). Conclusion: For obtaining long-term survival, curative resection would be necessary in patients with no more than one lymph node metastasis. Synopsis: In patients with biliary tract cancer, curative resection is necessary for long-term survival in patients with no more than one lymph node metastasis.

Original languageEnglish
Pages (from-to)145-151
Number of pages7
JournalInternational Journal of Surgery
Volume11
Issue number2
DOIs
Publication statusPublished - Jan 18 2013
Externally publishedYes

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Biliary Tract Neoplasms
Survivors
Lymph Nodes
Neoplasm Metastasis
Survival
Bile Duct Neoplasms
Gallbladder Neoplasms
Lymph Node Excision
Databases

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Clinicopathological features of long-term survivors for advanced biliary tract cancer and impact of the number of lymph nodes involved. / Kobayashi, Shogo; Nagano, Hiroaki; Marubashi, Shigeru; Kawamoto, Koichi; Wada, Hiroshi; Eguchi, Hidetoshi; Tanemura, Masahiro; Umeshita, Koji; Doki, Yuichiro; Mori, Masaki.

In: International Journal of Surgery, Vol. 11, No. 2, 18.01.2013, p. 145-151.

Research output: Contribution to journalArticle

Kobayashi, S, Nagano, H, Marubashi, S, Kawamoto, K, Wada, H, Eguchi, H, Tanemura, M, Umeshita, K, Doki, Y & Mori, M 2013, 'Clinicopathological features of long-term survivors for advanced biliary tract cancer and impact of the number of lymph nodes involved', International Journal of Surgery, vol. 11, no. 2, pp. 145-151. https://doi.org/10.1016/j.ijsu.2012.12.006
Kobayashi, Shogo ; Nagano, Hiroaki ; Marubashi, Shigeru ; Kawamoto, Koichi ; Wada, Hiroshi ; Eguchi, Hidetoshi ; Tanemura, Masahiro ; Umeshita, Koji ; Doki, Yuichiro ; Mori, Masaki. / Clinicopathological features of long-term survivors for advanced biliary tract cancer and impact of the number of lymph nodes involved. In: International Journal of Surgery. 2013 ; Vol. 11, No. 2. pp. 145-151.
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