Clinicopathological features of type 2 autoimmune pancreatitis in Japan: Results of a multicenter survey

Kenji Notohara, Isao Nishimori, Nobumasa Mizuno, Kazuichi Okazaki, Tetsuhide Ito, Shigeyuki Kawa, Shinichi Egawa, Yasuyuki Kihara, Atsushi Kanno, Atsushi Masamune, Tooru Shimosegawa

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10 Citations (Scopus)

Abstract

Objective: The aim of the study was to clarify clinicopathological features of type 2 autoimmune pancreatitis (AIP) in Japan; a multicenter survey was carried out. Methods: The first screening collected patients with pancreatitis whose pancreatic tissue samples were available and who fulfilled at least 1 of the following 3 criteria as possible type 2 AIP: (1) histological presence of granulocytic epithelial lesion, (2) age of 50 years or younger, and (3) association of ulcerative colitis, Sjogren syndrome, and/or primary biliary cirrhosis. Patients with histologically confirmed type 1 AIP were also collected as a control. Clinical information was gathered by questionnaire. Results: A histological re-evaluation identified 8 patients with type 2 AIP and 20 with type 1 AIP. Three of the latter had intralobular neutrophilic infiltration. Factors more frequent in type 2 included age younger than 40 years, abdominal pain, and elevation of serum amylase and lipase, whereas patientswith type 1 more frequently showed jaundice, elevated serum IgG and IgG4, presence of autoantibodies, association of IgG4-related disease, sclerosing cholangitis and diabetes mellitus, and imaging findings of intrapancreatic biliary stenosis and extrapancreatic biliary dilatation. Conclusions: The clinical features of type 2 AIP in Japan were similar to those of western countries. Intralobular neutrophilic infiltration in type 1 is a potential pitfall, especially in the biopsy-based diagnosis.

Original languageEnglish
Pages (from-to)1072-1077
Number of pages6
JournalPancreas
Volume44
Issue number7
DOIs
Publication statusPublished - Oct 1 2015

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Pancreatitis
Japan
Immunoglobulin G
Sclerosing Cholangitis
Biliary Liver Cirrhosis
Sjogren's Syndrome
Amylases
Jaundice
Surveys and Questionnaires
Serum
Lipase
Ulcerative Colitis
Autoantibodies
Abdominal Pain
Dilatation
Diabetes Mellitus
Pathologic Constriction
Biopsy

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

Cite this

Notohara, K., Nishimori, I., Mizuno, N., Okazaki, K., Ito, T., Kawa, S., ... Shimosegawa, T. (2015). Clinicopathological features of type 2 autoimmune pancreatitis in Japan: Results of a multicenter survey. Pancreas, 44(7), 1072-1077. https://doi.org/10.1097/MPA.0000000000000438

Clinicopathological features of type 2 autoimmune pancreatitis in Japan : Results of a multicenter survey. / Notohara, Kenji; Nishimori, Isao; Mizuno, Nobumasa; Okazaki, Kazuichi; Ito, Tetsuhide; Kawa, Shigeyuki; Egawa, Shinichi; Kihara, Yasuyuki; Kanno, Atsushi; Masamune, Atsushi; Shimosegawa, Tooru.

In: Pancreas, Vol. 44, No. 7, 01.10.2015, p. 1072-1077.

Research output: Contribution to journalArticle

Notohara, K, Nishimori, I, Mizuno, N, Okazaki, K, Ito, T, Kawa, S, Egawa, S, Kihara, Y, Kanno, A, Masamune, A & Shimosegawa, T 2015, 'Clinicopathological features of type 2 autoimmune pancreatitis in Japan: Results of a multicenter survey', Pancreas, vol. 44, no. 7, pp. 1072-1077. https://doi.org/10.1097/MPA.0000000000000438
Notohara, Kenji ; Nishimori, Isao ; Mizuno, Nobumasa ; Okazaki, Kazuichi ; Ito, Tetsuhide ; Kawa, Shigeyuki ; Egawa, Shinichi ; Kihara, Yasuyuki ; Kanno, Atsushi ; Masamune, Atsushi ; Shimosegawa, Tooru. / Clinicopathological features of type 2 autoimmune pancreatitis in Japan : Results of a multicenter survey. In: Pancreas. 2015 ; Vol. 44, No. 7. pp. 1072-1077.
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