Clinicopathological outline of dementia with Lewy bodies applying the revised criteria: The Hisayama study

Kouhei Fujimi, Kensuke Sasaki, Kazuhito Noda, Yoshinobu Wakisaka, Yumihiro Tanizaki, Yukiko Matsui, Atsuko Sekita, Mitsuo Iida, Yutaka Kiyohara, Shigenobu Kanba, Toru Iwaki

Research output: Contribution to journalArticlepeer-review

50 Citations (Scopus)

Abstract

To explore the validity of the criteria for dementia with Lewy bodies (DLB) revised in 2005, we examined community based consecutive autopsy cases. 10.3% of the non-demented subjects and 31.2% of the demented subjects showed the Lewy body pathology. Applying the revised pathological criteria to the 205 demented subjects, the types of LB pathology of 11 cases (5.4%) were brainstem- predominant, 24 cases (11.7%) were limbic type and 24 cases (11.7%) were diffuse neocortical type, although there were many subjects not to fit the criteria exactly. The prevalence of Lewy bodies (LBs) was almost same regardless of gender; however, the extent of the LB pathology among females was more severe than that in males. The likelihood of DLB being modified by concomitant Alzheimer's pathology was as follows: 27 cases (13.2%) showed low likelihood, 16 cases (7.8%) showed intermediate likelihood and 16 cases (7.8%) showed high likelihood. Since the numbers of clinical features of DLB were significantly higher in the pathological intermediate and high likelihood DLB groups than in the low likelihood DLB group or no LB group, both the intermediate and high likelihood groups of DLB should be considered as pathological DLB.

Original languageEnglish
Pages (from-to)317-325
Number of pages9
JournalBrain Pathology
Volume18
Issue number3
DOIs
Publication statusPublished - Jul 2008

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Neuroscience(all)
  • Clinical Neurology

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