Clinicopathological significance of pRb2/p130 expression in squamous cell carcinoma of the esophagus

T. Nozoe, D. Korenaga, S. Itoh, M. Futatsugi, Y. Maehara

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Purpose: The aim of the current study was to find out the significance of the immunohistochemical expression of pRb2/p130, which is a member of the retinoblastoma gene family, in squamous cell carcinoma of the esophagus. Methods: We analyzed immunohisto-chemically the expression of pRb2/p130 of 107 squamous cell carcinomas (SCCs) of the esophagus and the correlation of pRb2/p130 expression with clinicopathological features was investigated. Results: Expression of pRb2/p130 was observed in 42 SCCs (39.3%). There was a significant correlation of pRb2/p130 expression with the histological type of well-differentiated SCC (P < 0.0001). The survival rate of patients with esophageal SCCs expressing pRb2/p130 was significantly better than that of patients with tumors without pRb2/p130 expression (P = 0.016). A multivariate analysis demonstrated that pRb2/p130 expression (P = 0.026), venous invasion (P = 0.028), and TNM stage (P = 0.044) were independent prognostic indicators in patients with esophageal SCCs. Conclusions: Differentiation of esophageal SCC might be partially mediated by the pRb2/p130 gene, and pRb2/p130 expression can additionally be an indicator of the better prognosis of patients with esophageal SCCs.

Original languageEnglish
Pages (from-to)691-696
Number of pages6
JournalJournal of Cancer Research and Clinical Oncology
Volume128
Issue number12
DOIs
Publication statusPublished - 2002

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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