TY - JOUR
T1 - Clinicopathological study of 551 cases of major salivary gland tumors
AU - Yamamoto, Hidetaka
AU - Segawa, Yuichi
AU - Shiratsuchi, Hideki
AU - Hirakawa, Naoya
AU - Hashimoto, Kazuki
AU - Nakashima, Torahiko
AU - Komune, Shizuo
AU - Tsuneyoshi, Masazumi
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2008
Y1 - 2008
N2 - As salivary gland tumors have variable histological and biological characteristics, appropriate pathological diagnosis is necessary. We collected and reviewed 551 cases of salivary gland tumors which were surgically operated from 1983 to 2007 (24 years). The 551 cases were comprised of 537 epithelial tumors (97.5%), 10 hematolymphoid tumors and 4 mesenchymal tumors. The epithelial tumors were located in the parotid gland (475 cases) and submandibular gland (62 cases). Malignancies accounted for 123 (22.9%) of the 537 epithelial tumors. The frequency of malignancies was much higher in the submandibular gland (45.2%) than in the parotid gland (20%). The frequent histological types among all epithelial tumors were pleomorphic adenoma (285 cases; 53.1%), followed by Warthin's tumor (19.4%), and those among malignant epithelial tumors (carcinomas) were adenoid cystic carcinoma (25 cases), mucoepidermoid carcinoma (17) and carcinoma ex pleomorphic adenoma (15). The risk of malignant change of pleomorphic adenomas was estimated as 5% (15/300 cases). The histological subtypes of carcinoma ex pleomorphic adenoma varied among the cases, and in some cases were salivary duct carcinoma, which is a high-risk carcinoma that requires careful attention.
AB - As salivary gland tumors have variable histological and biological characteristics, appropriate pathological diagnosis is necessary. We collected and reviewed 551 cases of salivary gland tumors which were surgically operated from 1983 to 2007 (24 years). The 551 cases were comprised of 537 epithelial tumors (97.5%), 10 hematolymphoid tumors and 4 mesenchymal tumors. The epithelial tumors were located in the parotid gland (475 cases) and submandibular gland (62 cases). Malignancies accounted for 123 (22.9%) of the 537 epithelial tumors. The frequency of malignancies was much higher in the submandibular gland (45.2%) than in the parotid gland (20%). The frequent histological types among all epithelial tumors were pleomorphic adenoma (285 cases; 53.1%), followed by Warthin's tumor (19.4%), and those among malignant epithelial tumors (carcinomas) were adenoid cystic carcinoma (25 cases), mucoepidermoid carcinoma (17) and carcinoma ex pleomorphic adenoma (15). The risk of malignant change of pleomorphic adenomas was estimated as 5% (15/300 cases). The histological subtypes of carcinoma ex pleomorphic adenoma varied among the cases, and in some cases were salivary duct carcinoma, which is a high-risk carcinoma that requires careful attention.
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U2 - 10.5981/jjhnc.34.548
DO - 10.5981/jjhnc.34.548
M3 - Article
AN - SCOPUS:85009561640
VL - 34
SP - 548
EP - 551
JO - Japanese Journal of Head and Neck Cancer
JF - Japanese Journal of Head and Neck Cancer
SN - 1349-5747
IS - 4
ER -