Clonal expansion of superantigen-reactive T cells is resistant to FK506 in mice with AIDS

Yasunobu Yoshikai; Hiroyuki Kidokoro; Keiko Kimura; Yoshiyasu Aoki; Masahiko Makino; Kenji Hiromatsu

doi:10.1128/jvi.71.1.746-749.1997

Clonal expansion of superantigen-reactive T cells is resistant to FK506 in mice with AIDS

Yasunobu Yoshikai, Hiroyuki Kidokoro, Keiko Kimura, Yoshiyasu Aoki, Masahiko Makino, Kenji Hiromatsu

Research output: Contribution to journal › Article › peer-review

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Abstract

Subcutaneous injection of FK506 (10 mg/kg of body weight) completely blocked the clonal expansion of staphylococcal enterotoxin A (SEA)-reactive T cells in healthy (control) mice after SEA injection but did not disturb it in mice with murine AIDS (MAIDS) caused by infection with LP-BM5 murine leukemia virus. MAIDS mice are characterized by utilization of a FK506-insensitive pathway for clonal expansion of superantigen-reactive T cells.

Original language	English
Pages (from-to)	746-749
Number of pages	4
Journal	Journal of virology
Volume	71
Issue number	1
DOIs	https://doi.org/10.1128/jvi.71.1.746-749.1997
Publication status	Published - 1997

All Science Journal Classification (ASJC) codes

Microbiology
Immunology
Insect Science
Virology

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1128/jvi.71.1.746-749.1997

Cite this

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abstract = "Subcutaneous injection of FK506 (10 mg/kg of body weight) completely blocked the clonal expansion of staphylococcal enterotoxin A (SEA)-reactive T cells in healthy (control) mice after SEA injection but did not disturb it in mice with murine AIDS (MAIDS) caused by infection with LP-BM5 murine leukemia virus. MAIDS mice are characterized by utilization of a FK506-insensitive pathway for clonal expansion of superantigen-reactive T cells.",

author = "Yasunobu Yoshikai and Hiroyuki Kidokoro and Keiko Kimura and Yoshiyasu Aoki and Masahiko Makino and Kenji Hiromatsu",

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AU - Yoshikai, Yasunobu

AU - Kidokoro, Hiroyuki

AU - Kimura, Keiko

AU - Aoki, Yoshiyasu

AU - Makino, Masahiko

AU - Hiromatsu, Kenji

PY - 1997

Y1 - 1997

N2 - Subcutaneous injection of FK506 (10 mg/kg of body weight) completely blocked the clonal expansion of staphylococcal enterotoxin A (SEA)-reactive T cells in healthy (control) mice after SEA injection but did not disturb it in mice with murine AIDS (MAIDS) caused by infection with LP-BM5 murine leukemia virus. MAIDS mice are characterized by utilization of a FK506-insensitive pathway for clonal expansion of superantigen-reactive T cells.

AB - Subcutaneous injection of FK506 (10 mg/kg of body weight) completely blocked the clonal expansion of staphylococcal enterotoxin A (SEA)-reactive T cells in healthy (control) mice after SEA injection but did not disturb it in mice with murine AIDS (MAIDS) caused by infection with LP-BM5 murine leukemia virus. MAIDS mice are characterized by utilization of a FK506-insensitive pathway for clonal expansion of superantigen-reactive T cells.

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JF - Journal of Virology

IS - 1

ER -

Clonal expansion of superantigen-reactive T cells is resistant to FK506 in mice with AIDS

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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