Abstract
Study Objective: To test the hypothesis that clonidine premedication could prevent an increase of plasma epinephrine occurring as a result of anxiety, and a decrease of the serum potassium (K+) levels before the induction of anesthesia. Design: Randomized, double-blinded study.Setting: University Hospital of Seoul. Patients: 44 ASA physical status I and II patients, aged 20 to 50 years, scheduled for knee, ear, or nose surgery.Intervention: 44 patients were randomly allocated into one of two groups: 22 patients (clonidine group) received clonidine 300 μg orally at 120 minutes before the induction of anesthesia. The other 22 patients (control group) received a placebo. Measurements and Main Results: Anxiety level, serum K+, and plasma epinephrine were measured at an outpatient clinic, and immediately before the induction of anesthesia. There were no differences between groups in degree of anxiety experienced, serum K+, or plasma epinephrine levels as measured at the out-patient clinic. Immediately before the induction of anesthesia, the serum K+ levels of the clonidine group were higher than those of the control group (3.89 ± 0.26 mEq/L vs. 3.50 ± 0.36 mEq/L), and anxiety and plasma epinephrine levels of clonidine group were lower than those of the control group (p < 0.05). The frequency of hypokalemia (K+ ≤ 3.5 mEq/L) of the clonidine group immediately before the induction of anesthesia was significantly lower than that of the control group (0% vs. 50%). Conclusions: Clonidine premedication was effective in preventing hypokalemic episodes occurring before the induction of anesthesia.
| Original language | English |
|---|---|
| Pages (from-to) | 6-9 |
| Number of pages | 4 |
| Journal | Journal of Clinical Anesthesia |
| Volume | 14 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 1 2002 |
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All Science Journal Classification (ASJC) codes
- Anesthesiology and Pain Medicine
Cite this
Clonidine premedication prevents preoperative hypokalemia. / Hahm, Tae S.; Cho, Hyun S.; Lee, Kook Hyun; Chung, Ik S.; Kim, Ji A.; Kim, Myung H.
In: Journal of Clinical Anesthesia, Vol. 14, No. 1, 01.01.2002, p. 6-9.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Clonidine premedication prevents preoperative hypokalemia
AU - Hahm, Tae S.
AU - Cho, Hyun S.
AU - Lee, Kook Hyun
AU - Chung, Ik S.
AU - Kim, Ji A.
AU - Kim, Myung H.
PY - 2002/1/1
Y1 - 2002/1/1
N2 - Study Objective: To test the hypothesis that clonidine premedication could prevent an increase of plasma epinephrine occurring as a result of anxiety, and a decrease of the serum potassium (K+) levels before the induction of anesthesia. Design: Randomized, double-blinded study.Setting: University Hospital of Seoul. Patients: 44 ASA physical status I and II patients, aged 20 to 50 years, scheduled for knee, ear, or nose surgery.Intervention: 44 patients were randomly allocated into one of two groups: 22 patients (clonidine group) received clonidine 300 μg orally at 120 minutes before the induction of anesthesia. The other 22 patients (control group) received a placebo. Measurements and Main Results: Anxiety level, serum K+, and plasma epinephrine were measured at an outpatient clinic, and immediately before the induction of anesthesia. There were no differences between groups in degree of anxiety experienced, serum K+, or plasma epinephrine levels as measured at the out-patient clinic. Immediately before the induction of anesthesia, the serum K+ levels of the clonidine group were higher than those of the control group (3.89 ± 0.26 mEq/L vs. 3.50 ± 0.36 mEq/L), and anxiety and plasma epinephrine levels of clonidine group were lower than those of the control group (p < 0.05). The frequency of hypokalemia (K+ ≤ 3.5 mEq/L) of the clonidine group immediately before the induction of anesthesia was significantly lower than that of the control group (0% vs. 50%). Conclusions: Clonidine premedication was effective in preventing hypokalemic episodes occurring before the induction of anesthesia.
AB - Study Objective: To test the hypothesis that clonidine premedication could prevent an increase of plasma epinephrine occurring as a result of anxiety, and a decrease of the serum potassium (K+) levels before the induction of anesthesia. Design: Randomized, double-blinded study.Setting: University Hospital of Seoul. Patients: 44 ASA physical status I and II patients, aged 20 to 50 years, scheduled for knee, ear, or nose surgery.Intervention: 44 patients were randomly allocated into one of two groups: 22 patients (clonidine group) received clonidine 300 μg orally at 120 minutes before the induction of anesthesia. The other 22 patients (control group) received a placebo. Measurements and Main Results: Anxiety level, serum K+, and plasma epinephrine were measured at an outpatient clinic, and immediately before the induction of anesthesia. There were no differences between groups in degree of anxiety experienced, serum K+, or plasma epinephrine levels as measured at the out-patient clinic. Immediately before the induction of anesthesia, the serum K+ levels of the clonidine group were higher than those of the control group (3.89 ± 0.26 mEq/L vs. 3.50 ± 0.36 mEq/L), and anxiety and plasma epinephrine levels of clonidine group were lower than those of the control group (p < 0.05). The frequency of hypokalemia (K+ ≤ 3.5 mEq/L) of the clonidine group immediately before the induction of anesthesia was significantly lower than that of the control group (0% vs. 50%). Conclusions: Clonidine premedication was effective in preventing hypokalemic episodes occurring before the induction of anesthesia.
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U2 - 10.1016/S0952-8180(01)00342-7
DO - 10.1016/S0952-8180(01)00342-7
M3 - Article
C2 - 11880014
AN - SCOPUS:0036176546
VL - 14
SP - 6
EP - 9
JO - Journal of Clinical Anesthesia
JF - Journal of Clinical Anesthesia
SN - 0952-8180
IS - 1
ER -