Clonidine premedication prevents preoperative hypokalemia

Tae S. Hahm, Hyun S. Cho, Kook Hyun Lee, Ik S. Chung, Ji A. Kim, Myung H. Kim

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Study Objective: To test the hypothesis that clonidine premedication could prevent an increase of plasma epinephrine occurring as a result of anxiety, and a decrease of the serum potassium (K+) levels before the induction of anesthesia. Design: Randomized, double-blinded study.Setting: University Hospital of Seoul. Patients: 44 ASA physical status I and II patients, aged 20 to 50 years, scheduled for knee, ear, or nose surgery.Intervention: 44 patients were randomly allocated into one of two groups: 22 patients (clonidine group) received clonidine 300 μg orally at 120 minutes before the induction of anesthesia. The other 22 patients (control group) received a placebo. Measurements and Main Results: Anxiety level, serum K+, and plasma epinephrine were measured at an outpatient clinic, and immediately before the induction of anesthesia. There were no differences between groups in degree of anxiety experienced, serum K+, or plasma epinephrine levels as measured at the out-patient clinic. Immediately before the induction of anesthesia, the serum K+ levels of the clonidine group were higher than those of the control group (3.89 ± 0.26 mEq/L vs. 3.50 ± 0.36 mEq/L), and anxiety and plasma epinephrine levels of clonidine group were lower than those of the control group (p < 0.05). The frequency of hypokalemia (K+ ≤ 3.5 mEq/L) of the clonidine group immediately before the induction of anesthesia was significantly lower than that of the control group (0% vs. 50%). Conclusions: Clonidine premedication was effective in preventing hypokalemic episodes occurring before the induction of anesthesia.

Original languageEnglish
Pages (from-to)6-9
Number of pages4
JournalJournal of Clinical Anesthesia
Volume14
Issue number1
DOIs
Publication statusPublished - Jan 1 2002

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Hypokalemia
Premedication
Clonidine
Anesthesia
Epinephrine
Anxiety
Control Groups
Serum
Ambulatory Care Facilities
Nose
Ear
Knee
Potassium
Outpatients
Placebos

All Science Journal Classification (ASJC) codes

  • Anesthesiology and Pain Medicine

Cite this

Hahm, T. S., Cho, H. S., Lee, K. H., Chung, I. S., Kim, J. A., & Kim, M. H. (2002). Clonidine premedication prevents preoperative hypokalemia. Journal of Clinical Anesthesia, 14(1), 6-9. https://doi.org/10.1016/S0952-8180(01)00342-7

Clonidine premedication prevents preoperative hypokalemia. / Hahm, Tae S.; Cho, Hyun S.; Lee, Kook Hyun; Chung, Ik S.; Kim, Ji A.; Kim, Myung H.

In: Journal of Clinical Anesthesia, Vol. 14, No. 1, 01.01.2002, p. 6-9.

Research output: Contribution to journalArticle

Hahm, TS, Cho, HS, Lee, KH, Chung, IS, Kim, JA & Kim, MH 2002, 'Clonidine premedication prevents preoperative hypokalemia', Journal of Clinical Anesthesia, vol. 14, no. 1, pp. 6-9. https://doi.org/10.1016/S0952-8180(01)00342-7
Hahm, Tae S. ; Cho, Hyun S. ; Lee, Kook Hyun ; Chung, Ik S. ; Kim, Ji A. ; Kim, Myung H. / Clonidine premedication prevents preoperative hypokalemia. In: Journal of Clinical Anesthesia. 2002 ; Vol. 14, No. 1. pp. 6-9.
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