Cloning of a cDNA encoding a novel sugar transporter expressed in the neonatal mouse hippocampus

Naoki Matsuo, Shoko Kawamoto, Kenichi Matsubara, Kousaku Okubo

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

While analyzing active genes in the neonatal mouse hippocampus, we observed several novel genes that were abundantly expressed in this tissue. We report here cloning and sequencing of one of these tran scripts, HiAT1 (Hippocampus Abundant Gene Transcript 1). The mRNA was 2.7 Kb in length, and the deduced amino acid sequence consisted of 490 amino acids with characteristics typical of members of the sugar transporter family. However, its overall sequence homology to known transporter cDNAs was only about 30%, suggesting strongly that it represents a novel sugar transporter gene. Northern hybridization analyses showed this transcript is detected in adult and embryonic brains, as well as in other tissues.

Original languageEnglish
Pages (from-to)126-129
Number of pages4
JournalBiochemical and Biophysical Research Communications
Volume238
Issue number1
DOIs
Publication statusPublished - Sep 8 1997
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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