Cloning of B cell-specific membrane tetraspanning molecule BTS possessing B cell proliferation-inhibitory function

Tadahiro Suenaga, Hisashi Arase, Shou Yamasaki, Masayuki Kohno, Tadashi Yokosuka, Arata Takeuchi, Takamichi Hattori, Takashi Saito

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    10 Citations (Scopus)

    Abstract

    Lymphocyte proliferation is regulated by signals through antigen receptors, costimulatory receptors, and other positive and negative modulators. Several membrane tetraspanning molecules are also involved in the regulation of lymphocyte growth and death. We cloned a new B cell-specific tetraspanning (BTS) membrane molecule, which is similar to CD20 in terms of expression, structure and function. BTS is specifically expressed in the B cell line and its expression is increased after the pre-B cell stage. BTS is expressed in intracellular granules and on the cell surface. Overexpression of BTS in immature B cell lines induces growth retardation through inhibition of cell cycle progression and cell size increase without inducing apoptosis. This inhibitory function is mediated predominantly by the N terminus of BTS. The development of mature B cells is inhibited in transgenic mice expressing BTS, suggesting that BTS is involved in the in vivo regulation of B cells. These results indicate that BTS plays a role in the regulation of cell division and B cell growth.

    Original languageEnglish
    Pages (from-to)3197-3207
    Number of pages11
    JournalEuropean Journal of Immunology
    Volume37
    Issue number11
    DOIs
    Publication statusPublished - Nov 1 2007

    All Science Journal Classification (ASJC) codes

    • Immunology and Allergy
    • Immunology

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  • Cite this

    Suenaga, T., Arase, H., Yamasaki, S., Kohno, M., Yokosuka, T., Takeuchi, A., Hattori, T., & Saito, T. (2007). Cloning of B cell-specific membrane tetraspanning molecule BTS possessing B cell proliferation-inhibitory function. European Journal of Immunology, 37(11), 3197-3207. https://doi.org/10.1002/eji.200737052