Cloning of the human homolog of conductin (AXIN2), a gene mapping to chromosome 17q23-q24

Mai Ming, Chiping Qian, Akira Yokomizo, David I. Smith, Liu Wanguo

Research output: Contribution to journalArticle

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Abstract

Conductin or Axil, an Axin homolog, plays an important role in the regulation of β-catenin stability in the Wnt signaling pathway. To facilitate the molecular analysis of the human gene, we isolated the human homolog, AXIN2. The cDNA contains a 2529-bp open reading frame and encodes a putative protein of 843 amino acids. Compared with rat and mouse homologs, AXIN2 shows an overall 89% amino acid identity. Several functional domains in this protein are highly conserved including the GRS (95.9%), GSK-3β (96.3%), Dsh (98%), and β-catenin (89.9%) domains. Radiation hybrid mapping localized the AXIN2 gene to human chromosome 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Human AXIN2 is thus a very strong candidate involved in multiple tumor types.

Original languageEnglish
Pages (from-to)341-344
Number of pages4
JournalGenomics
Volume55
Issue number3
DOIs
Publication statusPublished - Feb 1 1999

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Chromosome Mapping
Organism Cloning
Catenins
Chromosomes
Radiation Hybrid Mapping
Glycogen Synthase Kinase 3
Amino Acids
Wnt Signaling Pathway
Loss of Heterozygosity
Human Chromosomes
Neuroblastoma
Open Reading Frames
Genes
Neoplasms
Complementary DNA
Breast Neoplasms
Proteins

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Cloning of the human homolog of conductin (AXIN2), a gene mapping to chromosome 17q23-q24. / Ming, Mai; Qian, Chiping; Yokomizo, Akira; Smith, David I.; Wanguo, Liu.

In: Genomics, Vol. 55, No. 3, 01.02.1999, p. 341-344.

Research output: Contribution to journalArticle

Ming, M, Qian, C, Yokomizo, A, Smith, DI & Wanguo, L 1999, 'Cloning of the human homolog of conductin (AXIN2), a gene mapping to chromosome 17q23-q24', Genomics, vol. 55, no. 3, pp. 341-344. https://doi.org/10.1006/geno.1998.5650
Ming, Mai ; Qian, Chiping ; Yokomizo, Akira ; Smith, David I. ; Wanguo, Liu. / Cloning of the human homolog of conductin (AXIN2), a gene mapping to chromosome 17q23-q24. In: Genomics. 1999 ; Vol. 55, No. 3. pp. 341-344.
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