Clorgyline inhibits orexin-a-induced arousal in layer-type chicks

Sachiko Katayama, Kazutaka Shigemi, Mark A. Cline, Mitsuhiro Furuse

Research output: Contribution to journalComment/debate

5 Citations (Scopus)

Abstract

We previously demonstrated that intracerebroventricular (ICV) injection of orexin-A induces arousal and increased metabolic turnover rates of norepinephrine, dopamine, and serotonin in layer (egg-type) chicks. Because monoamine oxidase-A (MAO-A) is a potent degrading enzyme of these monoamines, we hypothesized that orexin-A may mediate its arousal-inducing effects through MAOA. Therefore, we simultaneously injected clorgyline, a specific inhibitor of MAO-A, with orexin-A and examined behavior of chicks. Behaviors associated with arousal were attenuated in the group of chicks that received clorgyline and orexin-A compared with those that received orexin-A alone. For the monoamine turnover rate, enhancement of the turnover rate of serotonin by orexin-A was attenuated by clorgyline. Therefore, we conclude that orexin-A-induced arousal is dependent upon monoamine neural activities stimulated by MAO-A in chicks.

Original languageEnglish
Pages (from-to)471-474
Number of pages4
JournalJournal of Veterinary Medical Science
Volume73
Issue number4
DOIs
Publication statusPublished - Apr 1 2011

Fingerprint

Clorgyline
Arousal
amine oxidase (flavin-containing)
monoamines
chicks
serotonin
Monoamine Oxidase
norepinephrine
dopamine
Serotonin
injection
Orexins
enzymes
Ovum
Dopamine
Norepinephrine
Injections
Enzymes

All Science Journal Classification (ASJC) codes

  • veterinary(all)

Cite this

Clorgyline inhibits orexin-a-induced arousal in layer-type chicks. / Katayama, Sachiko; Shigemi, Kazutaka; Cline, Mark A.; Furuse, Mitsuhiro.

In: Journal of Veterinary Medical Science, Vol. 73, No. 4, 01.04.2011, p. 471-474.

Research output: Contribution to journalComment/debate

Katayama, Sachiko ; Shigemi, Kazutaka ; Cline, Mark A. ; Furuse, Mitsuhiro. / Clorgyline inhibits orexin-a-induced arousal in layer-type chicks. In: Journal of Veterinary Medical Science. 2011 ; Vol. 73, No. 4. pp. 471-474.
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