Cobb syndrome in an infant

Treatment with endovascular embolization and corticosteroid therapy: Case report

Akio Soeda, Nobuyuki Sakai, Koji Iihara, Izumi Nagata, Robin P. Humphreys, J. Gordon McComb, Randall T. Higashida, Paul H. Chapman

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

OBJECTIVE AND IMPORTANCE: Cobb syndrome is a rare clinical entity characterized by the combination of a vascular skin nevus and an angioma in the spinal canal at the same metamere. We present a case report of an infant with Cobb syndrome. CLINICAL PRESENTATION: A 5-month-old girl presented with cutaneous hemangioma of the thoracolumbar region (T5-T12) and paraparesis. The infant was examined by magnetic resonance imaging and aortography and was diagnosed with Cobb syndrome. INTERVENTION: The patient received orally administered prednisolone therapy and underwent endovascular embolization of paravertebral and spinal angiomas with the use of n-butyl-2-cyanoacrylate. Her symptoms improved by combined treatment with liquid embolization and corticosteroid therapy. CONCLUSION: Although Cobb syndrome has been reported in older children, it is extremely rare in infants. To our knowledge, this is the first report of an infant with Cobb syndrome treated with endovascular embolization and corticosteroid therapy. The combined treatment with corticosteroid therapy and endovascular embolization of cutaneomeningospinal angioma in Cobb syndrome seems effective in alleviating symptoms and minimizing morbidity.

Original languageEnglish
Pages (from-to)711-715
Number of pages5
JournalNeurosurgery
Volume52
Issue number3
DOIs
Publication statusPublished - Mar 1 2003
Externally publishedYes

Fingerprint

Adrenal Cortex Hormones
Hemangioma
Therapeutics
Enbucrilate
Paraparesis
Aortography
Skin
Spinal Canal
Nevus
Prednisolone
Blood Vessels
Magnetic Resonance Imaging
Morbidity

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology

Cite this

Cobb syndrome in an infant : Treatment with endovascular embolization and corticosteroid therapy: Case report. / Soeda, Akio; Sakai, Nobuyuki; Iihara, Koji; Nagata, Izumi; Humphreys, Robin P.; McComb, J. Gordon; Higashida, Randall T.; Chapman, Paul H.

In: Neurosurgery, Vol. 52, No. 3, 01.03.2003, p. 711-715.

Research output: Contribution to journalArticle

Soeda, A, Sakai, N, Iihara, K, Nagata, I, Humphreys, RP, McComb, JG, Higashida, RT & Chapman, PH 2003, 'Cobb syndrome in an infant: Treatment with endovascular embolization and corticosteroid therapy: Case report', Neurosurgery, vol. 52, no. 3, pp. 711-715. https://doi.org/10.1227/01.NEU.0000048483.21777.B7
Soeda, Akio ; Sakai, Nobuyuki ; Iihara, Koji ; Nagata, Izumi ; Humphreys, Robin P. ; McComb, J. Gordon ; Higashida, Randall T. ; Chapman, Paul H. / Cobb syndrome in an infant : Treatment with endovascular embolization and corticosteroid therapy: Case report. In: Neurosurgery. 2003 ; Vol. 52, No. 3. pp. 711-715.
@article{1aab3ff14c6c47b589c5a365b48fdbe4,
title = "Cobb syndrome in an infant: Treatment with endovascular embolization and corticosteroid therapy: Case report",
abstract = "OBJECTIVE AND IMPORTANCE: Cobb syndrome is a rare clinical entity characterized by the combination of a vascular skin nevus and an angioma in the spinal canal at the same metamere. We present a case report of an infant with Cobb syndrome. CLINICAL PRESENTATION: A 5-month-old girl presented with cutaneous hemangioma of the thoracolumbar region (T5-T12) and paraparesis. The infant was examined by magnetic resonance imaging and aortography and was diagnosed with Cobb syndrome. INTERVENTION: The patient received orally administered prednisolone therapy and underwent endovascular embolization of paravertebral and spinal angiomas with the use of n-butyl-2-cyanoacrylate. Her symptoms improved by combined treatment with liquid embolization and corticosteroid therapy. CONCLUSION: Although Cobb syndrome has been reported in older children, it is extremely rare in infants. To our knowledge, this is the first report of an infant with Cobb syndrome treated with endovascular embolization and corticosteroid therapy. The combined treatment with corticosteroid therapy and endovascular embolization of cutaneomeningospinal angioma in Cobb syndrome seems effective in alleviating symptoms and minimizing morbidity.",
author = "Akio Soeda and Nobuyuki Sakai and Koji Iihara and Izumi Nagata and Humphreys, {Robin P.} and McComb, {J. Gordon} and Higashida, {Randall T.} and Chapman, {Paul H.}",
year = "2003",
month = "3",
day = "1",
doi = "10.1227/01.NEU.0000048483.21777.B7",
language = "English",
volume = "52",
pages = "711--715",
journal = "Neurosurgery",
issn = "0148-396X",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Cobb syndrome in an infant

T2 - Treatment with endovascular embolization and corticosteroid therapy: Case report

AU - Soeda, Akio

AU - Sakai, Nobuyuki

AU - Iihara, Koji

AU - Nagata, Izumi

AU - Humphreys, Robin P.

AU - McComb, J. Gordon

AU - Higashida, Randall T.

AU - Chapman, Paul H.

PY - 2003/3/1

Y1 - 2003/3/1

N2 - OBJECTIVE AND IMPORTANCE: Cobb syndrome is a rare clinical entity characterized by the combination of a vascular skin nevus and an angioma in the spinal canal at the same metamere. We present a case report of an infant with Cobb syndrome. CLINICAL PRESENTATION: A 5-month-old girl presented with cutaneous hemangioma of the thoracolumbar region (T5-T12) and paraparesis. The infant was examined by magnetic resonance imaging and aortography and was diagnosed with Cobb syndrome. INTERVENTION: The patient received orally administered prednisolone therapy and underwent endovascular embolization of paravertebral and spinal angiomas with the use of n-butyl-2-cyanoacrylate. Her symptoms improved by combined treatment with liquid embolization and corticosteroid therapy. CONCLUSION: Although Cobb syndrome has been reported in older children, it is extremely rare in infants. To our knowledge, this is the first report of an infant with Cobb syndrome treated with endovascular embolization and corticosteroid therapy. The combined treatment with corticosteroid therapy and endovascular embolization of cutaneomeningospinal angioma in Cobb syndrome seems effective in alleviating symptoms and minimizing morbidity.

AB - OBJECTIVE AND IMPORTANCE: Cobb syndrome is a rare clinical entity characterized by the combination of a vascular skin nevus and an angioma in the spinal canal at the same metamere. We present a case report of an infant with Cobb syndrome. CLINICAL PRESENTATION: A 5-month-old girl presented with cutaneous hemangioma of the thoracolumbar region (T5-T12) and paraparesis. The infant was examined by magnetic resonance imaging and aortography and was diagnosed with Cobb syndrome. INTERVENTION: The patient received orally administered prednisolone therapy and underwent endovascular embolization of paravertebral and spinal angiomas with the use of n-butyl-2-cyanoacrylate. Her symptoms improved by combined treatment with liquid embolization and corticosteroid therapy. CONCLUSION: Although Cobb syndrome has been reported in older children, it is extremely rare in infants. To our knowledge, this is the first report of an infant with Cobb syndrome treated with endovascular embolization and corticosteroid therapy. The combined treatment with corticosteroid therapy and endovascular embolization of cutaneomeningospinal angioma in Cobb syndrome seems effective in alleviating symptoms and minimizing morbidity.

UR - http://www.scopus.com/inward/record.url?scp=0037369790&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037369790&partnerID=8YFLogxK

U2 - 10.1227/01.NEU.0000048483.21777.B7

DO - 10.1227/01.NEU.0000048483.21777.B7

M3 - Article

VL - 52

SP - 711

EP - 715

JO - Neurosurgery

JF - Neurosurgery

SN - 0148-396X

IS - 3

ER -