TY - JOUR
T1 - Cocktail of reactive species generated by cold atmospheric plasma
T2 - Oral administration induces non-small cell lung cancer cell death
AU - Song, Chang Hyun
AU - Attri, Pankaj
AU - Ku, Sae Kwang
AU - Han, Ihn
AU - Bogaerts, Annemie
AU - Choi, Eun Ha
N1 - Funding Information:
We gratefully acknowledge financial support from the Leading Foreign Research Institute Recruitment program (Grant # NRF-2016K1A4A3914113) through the Basic Science Research Program of the National Research Foundation (NRF) of Korea and in part by Kwangwoon University.
Publisher Copyright:
© 2021 IOP Publishing Ltd.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/5/6
Y1 - 2021/5/6
N2 - Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, with 85% of all lung cancer reported as NSCLC. Moreover, there are no effective treatments in advanced NSCLC. This study shows for the first time that oral administration of plasma-treated water (PTW) can cure advanced NSCLC. The cold plasma in water generates a cocktail of reactive species, and oral administration of this cocktail to mice showed no toxicities even at the highest dose of PTW, after a single dose and repeated doses for 28 d in mice. In vivo studies reveal that PTW showed favorable anticancer effects on chemo-resistant lung cancer, similarly to gefitinib treatment as a reference drug in a chemo-resistant NSCLC model. The anticancer activities of PTW seem to be involved in inhibiting proliferation and angiogenesis and enhancing apoptosis in the cancer cells. Interestingly, the PTW contributes to enhanced immune response and improved cachexia in the model.
AB - Non-small cell lung cancer (NSCLC) is the most common type of lung cancer, with 85% of all lung cancer reported as NSCLC. Moreover, there are no effective treatments in advanced NSCLC. This study shows for the first time that oral administration of plasma-treated water (PTW) can cure advanced NSCLC. The cold plasma in water generates a cocktail of reactive species, and oral administration of this cocktail to mice showed no toxicities even at the highest dose of PTW, after a single dose and repeated doses for 28 d in mice. In vivo studies reveal that PTW showed favorable anticancer effects on chemo-resistant lung cancer, similarly to gefitinib treatment as a reference drug in a chemo-resistant NSCLC model. The anticancer activities of PTW seem to be involved in inhibiting proliferation and angiogenesis and enhancing apoptosis in the cancer cells. Interestingly, the PTW contributes to enhanced immune response and improved cachexia in the model.
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U2 - 10.1088/1361-6463/abdff2
DO - 10.1088/1361-6463/abdff2
M3 - Article
AN - SCOPUS:85102530180
SN - 0022-3727
VL - 54
JO - Journal Physics D: Applied Physics
JF - Journal Physics D: Applied Physics
IS - 18
M1 - abdff2
ER -
