Coenzyme models. Part 16. Studies of general-acid catalysis in the NADH model reduction

Seiji Shinkai, Hisatake Hamada, Yumiko Kusano, Osamu Manabe

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)

Abstract

The reduction of trifluoroacetophenone was performed in an aqueous acetate (and analogues) buffer solution with an acid-stable NADH model compound, 1-benzyl-3-carbamoyl-1,4-dihydroquinoline. The resultant Brönsted plots had a slope of -0.20, indicating that the reduction process is general-acid catalysed. This is the first example of general-acid catalysis observed in an NADH model reduction performed in an aqueous system.

Original languageEnglish
Pages (from-to)699-702
Number of pages4
JournalJournal of the Chemical Society, Perkin Transactions 2
Issue number5
DOIs
Publication statusPublished - Jan 1 1979
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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