Coenzyme models. Part 16. Studies of general-acid catalysis in the NADH model reduction

Seiji Shinkai, Hisatake Hamada, Yumiko Kusano, Osamu Manabe

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

The reduction of trifluoroacetophenone was performed in an aqueous acetate (and analogues) buffer solution with an acid-stable NADH model compound, 1-benzyl-3-carbamoyl-1,4-dihydroquinoline. The resultant Brönsted plots had a slope of -0.20, indicating that the reduction process is general-acid catalysed. This is the first example of general-acid catalysis observed in an NADH model reduction performed in an aqueous system.

Original languageEnglish
Pages (from-to)699-702
Number of pages4
JournalJournal of the Chemical Society, Perkin Transactions 2
Issue number5
DOIs
Publication statusPublished - Jan 1 1979

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Coenzymes
NAD
Catalysis
Acids
Buffers
Acetates

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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Coenzyme models. Part 16. Studies of general-acid catalysis in the NADH model reduction. / Shinkai, Seiji; Hamada, Hisatake; Kusano, Yumiko; Manabe, Osamu.

In: Journal of the Chemical Society, Perkin Transactions 2, No. 5, 01.01.1979, p. 699-702.

Research output: Contribution to journalArticle

Shinkai, Seiji ; Hamada, Hisatake ; Kusano, Yumiko ; Manabe, Osamu. / Coenzyme models. Part 16. Studies of general-acid catalysis in the NADH model reduction. In: Journal of the Chemical Society, Perkin Transactions 2. 1979 ; No. 5. pp. 699-702.
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