Coexpression of Grb7 with epidermal growth factor receptor or Her2/erbB2 in human advanced esophageal carcinoma

Shinji Tanaka, Masaki Mori, Tsuyoshi Akiyoshi, Youichi Tanaka, Ken Ichi Mafune, Jack R. Wands, Keizo Sugimachi

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Abstract

Growth factor receptors transmit intracellular signals that may be important in carcinogenesis. The Grb7 protein was recently identified as a substrate of the epidermal growth factor receptor and related Her2/erbB2 receptor-linked tyrosine kinase activity. The Grb7 gene has been found to be coamplified with Her2/erbB2 in breast carcinomas. In this study, Grb7 expression was studied in 32 human esophageal cancers. A human Grb7 cDNA encoding for N-terminal amino acids was isolated and found to be 90% homologous to the murine counterpart. Although there was no amplification of the Grb7 gene in esophageal cancers, Grb7 mRNA was found to be overexpressed in 14 cancers (43.8%) but not in adjacent normal esophageal mucosa. It is noteworthy that coexpression of Grb7 with epidermal growth factor receptor or Her2/erbB2 was detected in 10 esophageal carcinomas (31.3%) and was significantly related to extramucosal tumor invasion (P = 0.02), whereas such a relationship was not shown by each sole expression. These findings suggest a possible relationship of Grb7 signaling in association with expression of tyrosine kinase receptors in aggressive human esophageal cancer.

Original languageEnglish
Pages (from-to)28-31
Number of pages4
JournalCancer Research
Volume57
Issue number1
Publication statusPublished - Jan 18 1997

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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    Tanaka, S., Mori, M., Akiyoshi, T., Tanaka, Y., Mafune, K. I., Wands, J. R., & Sugimachi, K. (1997). Coexpression of Grb7 with epidermal growth factor receptor or Her2/erbB2 in human advanced esophageal carcinoma. Cancer Research, 57(1), 28-31.