Co(II)/Co(I) reduction-induced axial histidine-flipping in myoglobin reconstituted with a cobalt tetradehydrocorrin as a methionine synthase model

Takashi Hayashi; Yoshitsugu Morita; Eiichi Mizohata; Koji Oohora; Jun Ohbayashi; Tsuyoshi Inoue; Yoshio Hisaeda

doi:10.1039/c4cc05448b

Co(II)/Co(I) reduction-induced axial histidine-flipping in myoglobin reconstituted with a cobalt tetradehydrocorrin as a methionine synthase model

Takashi Hayashi, Yoshitsugu Morita, Eiichi Mizohata, Koji Oohora, Jun Ohbayashi, Tsuyoshi Inoue, Yoshio Hisaeda

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

A conjugate between apomyoglobin and cobalt tetradehydrocorrin was prepared to replicate the coordination behavior of cob(I)alamin in methionine synthase. X-ray crystallography reveals that the tetra-coordinated Co(I) species is formed through the cleavage of the axial Co-His93 ligation after the reduction of the penta-coordinated Co(II) cofactor in the heme pocket.

Original language	English
Pages (from-to)	12560-12563
Number of pages	4
Journal	Chemical Communications
Volume	50
Issue number	83
DOIs	https://doi.org/10.1039/c4cc05448b
Publication status	Published - Sept 18 2014

All Science Journal Classification (ASJC) codes

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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abstract = "A conjugate between apomyoglobin and cobalt tetradehydrocorrin was prepared to replicate the coordination behavior of cob(I)alamin in methionine synthase. X-ray crystallography reveals that the tetra-coordinated Co(I) species is formed through the cleavage of the axial Co-His93 ligation after the reduction of the penta-coordinated Co(II) cofactor in the heme pocket.",

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AU - Hayashi, Takashi

AU - Morita, Yoshitsugu

AU - Mizohata, Eiichi

AU - Oohora, Koji

AU - Ohbayashi, Jun

AU - Inoue, Tsuyoshi

AU - Hisaeda, Yoshio

PY - 2014/9/18

Y1 - 2014/9/18

N2 - A conjugate between apomyoglobin and cobalt tetradehydrocorrin was prepared to replicate the coordination behavior of cob(I)alamin in methionine synthase. X-ray crystallography reveals that the tetra-coordinated Co(I) species is formed through the cleavage of the axial Co-His93 ligation after the reduction of the penta-coordinated Co(II) cofactor in the heme pocket.

AB - A conjugate between apomyoglobin and cobalt tetradehydrocorrin was prepared to replicate the coordination behavior of cob(I)alamin in methionine synthase. X-ray crystallography reveals that the tetra-coordinated Co(I) species is formed through the cleavage of the axial Co-His93 ligation after the reduction of the penta-coordinated Co(II) cofactor in the heme pocket.

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JO - Chemical Communications

JF - Chemical Communications

IS - 83

ER -

Co(II)/Co(I) reduction-induced axial histidine-flipping in myoglobin reconstituted with a cobalt tetradehydrocorrin as a methionine synthase model

Abstract

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