Colloidal nanoparticles from Poly(N-isopropylacrylamide)-graft-DNA for single nucleotide discrimination based on salt-induced aggregation: Extension to long target DNA

Zhonglan Tang; Tohru Takarada; Yoshikuni Sato; Mizuo Maeda

doi:10.1246/cl.2004.1602

Colloidal nanoparticles from Poly(N-isopropylacrylamide)-graft-DNA for single nucleotide discrimination based on salt-induced aggregation: Extension to long target DNA

Zhonglan Tang, Tohru Takarada, Yoshikuni Sato, Mizuo Maeda

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

The DNA-linked colloidal nanoparticle was prepared through the phase transition of the amphiphilic copolymer consisting of DNA as the hydrophilic part and thermo-responsive poly(N-isopropylacrylamide) as the hydrophobic part. We have succeeded in detecting the single nucleotide difference of 39-mer target DNA by using a salt-induced aggregation of the particles.

Original language	English
Pages (from-to)	1602-1603
Number of pages	2
Journal	Chemistry Letters
Volume	33
Issue number	12
DOIs	https://doi.org/10.1246/cl.2004.1602
Publication status	Published - Dec 5 2004
Externally published	Yes

All Science Journal Classification (ASJC) codes

Chemistry(all)

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10.1246/cl.2004.1602

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abstract = "The DNA-linked colloidal nanoparticle was prepared through the phase transition of the amphiphilic copolymer consisting of DNA as the hydrophilic part and thermo-responsive poly(N-isopropylacrylamide) as the hydrophobic part. We have succeeded in detecting the single nucleotide difference of 39-mer target DNA by using a salt-induced aggregation of the particles.",

author = "Zhonglan Tang and Tohru Takarada and Yoshikuni Sato and Mizuo Maeda",

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AU - Tang, Zhonglan

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AU - Sato, Yoshikuni

AU - Maeda, Mizuo

PY - 2004/12/5

Y1 - 2004/12/5

N2 - The DNA-linked colloidal nanoparticle was prepared through the phase transition of the amphiphilic copolymer consisting of DNA as the hydrophilic part and thermo-responsive poly(N-isopropylacrylamide) as the hydrophobic part. We have succeeded in detecting the single nucleotide difference of 39-mer target DNA by using a salt-induced aggregation of the particles.

AB - The DNA-linked colloidal nanoparticle was prepared through the phase transition of the amphiphilic copolymer consisting of DNA as the hydrophilic part and thermo-responsive poly(N-isopropylacrylamide) as the hydrophobic part. We have succeeded in detecting the single nucleotide difference of 39-mer target DNA by using a salt-induced aggregation of the particles.

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Colloidal nanoparticles from Poly(N-isopropylacrylamide)-graft-DNA for single nucleotide discrimination based on salt-induced aggregation: Extension to long target DNA

Abstract

All Science Journal Classification (ASJC) codes

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