Colocalization of scavenger receptor in CD68 positive foam cells in verruciform xanthoma

Masutaka Furue, Hiroshi Suzuki, Tatsuhiko Kodama, Tetsuo Hiramoto, Hideaki Sugiyama, Kunihiko Tamaki

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Verruciform xanthoma is a rare variant of xanthoma that appears predominantly on oral mucosa and the anogenital area. The histologic features are characterized by marked accumulation of foam cells in the papillary dermis with verrucous epidermal acanthosis and hyperkeratosis. However, little is known of the nature or origin of foam cells. Recent studies have emphasized the crucial role of macrophage scavenger receptors in the formation of foam cells in atherogenesis. We examined the immunohistologic localization of scavenger receptors in genital verruciform xanthoma. We found that the massively infiltrated foam cells in the papillary dermis were CD68+ monocyte-macrophage lineage cells, and that the majority of CD68+ cells coexpressed scavenger receptors. The in situ staining pattern of scavenger receptor in foam cells was mainly of an intracytoplasmic vacuolar pattern similar to that of dermal resident macrophages found in normal skin. Furthermore, CDla+ Langerhans cells, completely negative for scavenger receptor, were markedly decreased in number in verruciform xanthoma. These results indicate that scavenger receptor-bearing CD68+ cells are also actively involved in the development of cutaneous verruciform xanthoma, as has been shown to be the case in atherogenesis.

Original languageEnglish
Pages (from-to)213-219
Number of pages7
JournalJournal of Dermatological Science
Volume10
Issue number3
DOIs
Publication statusPublished - Nov 1995
Externally publishedYes

Fingerprint

Xanthomatosis
Scavenger Receptors
Foam Cells
Foams
Macrophages
Dermis
Skin
Atherosclerosis
Bearings (structural)
Langerhans Cells
Mouth Mucosa
Monocytes
Staining and Labeling

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Dermatology

Cite this

Colocalization of scavenger receptor in CD68 positive foam cells in verruciform xanthoma. / Furue, Masutaka; Suzuki, Hiroshi; Kodama, Tatsuhiko; Hiramoto, Tetsuo; Sugiyama, Hideaki; Tamaki, Kunihiko.

In: Journal of Dermatological Science, Vol. 10, No. 3, 11.1995, p. 213-219.

Research output: Contribution to journalArticle

Furue, Masutaka ; Suzuki, Hiroshi ; Kodama, Tatsuhiko ; Hiramoto, Tetsuo ; Sugiyama, Hideaki ; Tamaki, Kunihiko. / Colocalization of scavenger receptor in CD68 positive foam cells in verruciform xanthoma. In: Journal of Dermatological Science. 1995 ; Vol. 10, No. 3. pp. 213-219.
@article{1b733a7dd7c54fe4a2674824097b3339,
title = "Colocalization of scavenger receptor in CD68 positive foam cells in verruciform xanthoma",
abstract = "Verruciform xanthoma is a rare variant of xanthoma that appears predominantly on oral mucosa and the anogenital area. The histologic features are characterized by marked accumulation of foam cells in the papillary dermis with verrucous epidermal acanthosis and hyperkeratosis. However, little is known of the nature or origin of foam cells. Recent studies have emphasized the crucial role of macrophage scavenger receptors in the formation of foam cells in atherogenesis. We examined the immunohistologic localization of scavenger receptors in genital verruciform xanthoma. We found that the massively infiltrated foam cells in the papillary dermis were CD68+ monocyte-macrophage lineage cells, and that the majority of CD68+ cells coexpressed scavenger receptors. The in situ staining pattern of scavenger receptor in foam cells was mainly of an intracytoplasmic vacuolar pattern similar to that of dermal resident macrophages found in normal skin. Furthermore, CDla+ Langerhans cells, completely negative for scavenger receptor, were markedly decreased in number in verruciform xanthoma. These results indicate that scavenger receptor-bearing CD68+ cells are also actively involved in the development of cutaneous verruciform xanthoma, as has been shown to be the case in atherogenesis.",
author = "Masutaka Furue and Hiroshi Suzuki and Tatsuhiko Kodama and Tetsuo Hiramoto and Hideaki Sugiyama and Kunihiko Tamaki",
year = "1995",
month = "11",
doi = "10.1016/0923-1811(95)00406-I",
language = "English",
volume = "10",
pages = "213--219",
journal = "Journal of Dermatological Science",
issn = "0923-1811",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

TY - JOUR

T1 - Colocalization of scavenger receptor in CD68 positive foam cells in verruciform xanthoma

AU - Furue, Masutaka

AU - Suzuki, Hiroshi

AU - Kodama, Tatsuhiko

AU - Hiramoto, Tetsuo

AU - Sugiyama, Hideaki

AU - Tamaki, Kunihiko

PY - 1995/11

Y1 - 1995/11

N2 - Verruciform xanthoma is a rare variant of xanthoma that appears predominantly on oral mucosa and the anogenital area. The histologic features are characterized by marked accumulation of foam cells in the papillary dermis with verrucous epidermal acanthosis and hyperkeratosis. However, little is known of the nature or origin of foam cells. Recent studies have emphasized the crucial role of macrophage scavenger receptors in the formation of foam cells in atherogenesis. We examined the immunohistologic localization of scavenger receptors in genital verruciform xanthoma. We found that the massively infiltrated foam cells in the papillary dermis were CD68+ monocyte-macrophage lineage cells, and that the majority of CD68+ cells coexpressed scavenger receptors. The in situ staining pattern of scavenger receptor in foam cells was mainly of an intracytoplasmic vacuolar pattern similar to that of dermal resident macrophages found in normal skin. Furthermore, CDla+ Langerhans cells, completely negative for scavenger receptor, were markedly decreased in number in verruciform xanthoma. These results indicate that scavenger receptor-bearing CD68+ cells are also actively involved in the development of cutaneous verruciform xanthoma, as has been shown to be the case in atherogenesis.

AB - Verruciform xanthoma is a rare variant of xanthoma that appears predominantly on oral mucosa and the anogenital area. The histologic features are characterized by marked accumulation of foam cells in the papillary dermis with verrucous epidermal acanthosis and hyperkeratosis. However, little is known of the nature or origin of foam cells. Recent studies have emphasized the crucial role of macrophage scavenger receptors in the formation of foam cells in atherogenesis. We examined the immunohistologic localization of scavenger receptors in genital verruciform xanthoma. We found that the massively infiltrated foam cells in the papillary dermis were CD68+ monocyte-macrophage lineage cells, and that the majority of CD68+ cells coexpressed scavenger receptors. The in situ staining pattern of scavenger receptor in foam cells was mainly of an intracytoplasmic vacuolar pattern similar to that of dermal resident macrophages found in normal skin. Furthermore, CDla+ Langerhans cells, completely negative for scavenger receptor, were markedly decreased in number in verruciform xanthoma. These results indicate that scavenger receptor-bearing CD68+ cells are also actively involved in the development of cutaneous verruciform xanthoma, as has been shown to be the case in atherogenesis.

UR - http://www.scopus.com/inward/record.url?scp=0028792238&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028792238&partnerID=8YFLogxK

U2 - 10.1016/0923-1811(95)00406-I

DO - 10.1016/0923-1811(95)00406-I

M3 - Article

C2 - 8593263

AN - SCOPUS:0028792238

VL - 10

SP - 213

EP - 219

JO - Journal of Dermatological Science

JF - Journal of Dermatological Science

SN - 0923-1811

IS - 3

ER -