We have previously reported basic data on the specificity of the color reaction of 3,4-methylenedioxymethamphetamine (MDMA) and related drugs with chromotropic acid (CTA) and sulfuric acid. In this communication, we report an extended line of experiments that optimized reaction conditions, and we describe the application of this method to screening for MDMA or 3,4- methylendioxyamphetamine (MDA) in seized tablets. The optimal concentration of CTA and optimal reaction time at room temperature were 1.0 mM and 30 min, respectively. Final concentrations of MDMA of less than 100 μM should be used to avoid nonspecific color development. The CTA-dependent color reaction was also studied using aqueous extracts from seized tablets containing MDMA or MDA. On the basis of our results, we conclude that the present procedure is useful for screening for MDMA and MDA in seized tablets.
All Science Journal Classification (ASJC) codes
- Pathology and Forensic Medicine
- Biochemistry, medical