TY - JOUR
T1 - Color representation is retinotopically biased but locally intermingled in mouse V1
AU - Aihara, Shuhei
AU - Yoshida, Takashi
AU - Hashimoto, Takayuki
AU - Ohki, Kenichi
N1 - Funding Information:
We appreciate Dr. K. Koide (Toyohashi University of Technology) for discussion and technical advice, Dr. M. Leiwe (RIKEN) for valuable comments on the manuscript, A. Honda and Y. Sono (Kyushu University) for animal care and genotyping, M. Shigematsu for support of wide-field Ca2+ imaging experiment, all of the members of Ohki laboratory for support and discussion, and the Research Support Center, Graduate School of Medical Sciences, Kyushu University for technical support. This work was supported by grants from Core Research for Evolutionary Science and Technology (CREST)—Japan Agency for Medical Research and Development (AMED) (to KO), Japan Society for the Promotion of Science (JSPS) KAKENHI (Grant number 25221001 and 25117004 to KO and 15K16573 to TY), Brain Mapping by Integrated Neurotechnologies for Disease Studies (Brain/MINDS)—AMED, Strategic International Research Cooperative Program (SICP)—AMED (to KO) and RIKEN Junior Research Associate Program to SA.
Publisher Copyright:
©2017 Aihara, Yoshida, Hashimoto and Ohki.
PY - 2017/3/29
Y1 - 2017/3/29
N2 - Dichromatic vision is common in many mammals. However, color processing in the primary visual cortex (V1) of dichromatic mammals is relatively unknown compared to the trichromatic primates. In this study, we investigated the functional organization of color processing in mouse V1. The mouse retina has a graded expression pattern of two opsins along its dorsoventral axis. However, it is not clear whether and how this expression pattern is reflected in the cortical representation at local (several hundred microns) and areal (V1) level. Using in vivo two-photon calcium (Ca2+) imaging and wide-field Ca2+ imaging, we revealed that V1 neurons responded to S (UV)- and M (green)-opsin isolating stimuli with slightly biased color preference depending on retinotopic position in V1. This was consistent with the distribution of retinal opsins. At the cellular level, preferences for S- and M-opsin isolating stimuli were intermingled in a local region encompassing several hundred microns. These results suggest that functional organizations of color information are locally intermingled, but slightly biased depending on the retinotopic position in mouse V1.
AB - Dichromatic vision is common in many mammals. However, color processing in the primary visual cortex (V1) of dichromatic mammals is relatively unknown compared to the trichromatic primates. In this study, we investigated the functional organization of color processing in mouse V1. The mouse retina has a graded expression pattern of two opsins along its dorsoventral axis. However, it is not clear whether and how this expression pattern is reflected in the cortical representation at local (several hundred microns) and areal (V1) level. Using in vivo two-photon calcium (Ca2+) imaging and wide-field Ca2+ imaging, we revealed that V1 neurons responded to S (UV)- and M (green)-opsin isolating stimuli with slightly biased color preference depending on retinotopic position in V1. This was consistent with the distribution of retinal opsins. At the cellular level, preferences for S- and M-opsin isolating stimuli were intermingled in a local region encompassing several hundred microns. These results suggest that functional organizations of color information are locally intermingled, but slightly biased depending on the retinotopic position in mouse V1.
UR - http://www.scopus.com/inward/record.url?scp=85019185949&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85019185949&partnerID=8YFLogxK
U2 - 10.3389/fncir.2017.00022
DO - 10.3389/fncir.2017.00022
M3 - Article
C2 - 28405186
AN - SCOPUS:85019185949
SN - 1662-5110
VL - 11
JO - Frontiers in Neural Circuits
JF - Frontiers in Neural Circuits
M1 - 22
ER -