Colorectal endoscopic submucosal dissection using novel articulating devices: a comparative study in a live porcine model

Yasuharu Okamoto, Ryu Nakadate, Shotaro Nakamura, Jumpei Arata, Susumu Oguri, Tomohiko Moriyama, Motohiro Esaki, Tsutomu Iwasa, Kenoki Ohuchida, Tomohiko Akahoshi, Tetsuo Ikeda, Takanari Kitazono, Makoto Hashizume

Research output: Contribution to journalArticle

Abstract

Background and aims: Colonic endoscopic submucosal dissection (ESD) is time-consuming and bears a high risk of perforation. The aim of the present study was to compare the safety and efficacy between novel articulating devices and conventional ESD in live porcine colon models. Methods: Thirty ESDs in ten pigs were carried out at three different locations (15, 25, and 35 cm from the anus) by the conventional method (n = 15) and by the new method (n = 15). Procedure times, adverse events (perforation, bleeding), and damage to the muscular layer were recorded, and the ESD time per unit area of the specimens was calculated. Results: The perforation rate using the conventional method was 6.7% (1/15), whereas that using the new method was 0.0%. The number of sites of muscular damage was significantly lower in the new than conventional method (6 vs. 37, respectively; P = 0.024). The mean procedure time was significantly shorter in the new than conventional method (4.6 ± 2.0 vs. 7.0 ± 4.1 min/cm 2 , respectively; P = 0.042). Conclusions: Use of the new ESD method allows for reduced adverse events and a shortened resection time.

Original languageEnglish
Pages (from-to)651-657
Number of pages7
JournalSurgical endoscopy
Volume33
Issue number2
DOIs
Publication statusPublished - Feb 15 2019

All Science Journal Classification (ASJC) codes

  • Surgery

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