Colorectal polypectomy and risk of colorectal cancer by subsite: The Fukuoka colorectal cancer study

Daigo Yoshida, Suminori Kono, Malcolm A. Moore, Kengo Toyomura, Jun Nagano, Tetsuya Mizoue, Ryuichi Mibu, Masao Tanaka, Yoshihiro Kakeji, Yoshihiko Maehara, Takeshi Okamura, Koji Ikejiri, Kitaroh Futami, Yohichi Yasunami, Takafumi Maekawa, Kenji Takenaka, Hitoshi Ichimiya, Nobutoshi Imaizumi

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Abstract

Background: Colorectal adenomas are well-established precursor lesions for colorectal cancer and removal of polyps is deemed to reduce the risk of colorectal cancer. However, benefit of colorectal polypectomy in routine practice is still uncertain. We therefore investigated subsite-specific risks of colorectal cancer in relation to history of colorectal polypectomy in a case-control study. Methods: Both case patients and control subjects were residents aged 20-74 years in Fukuoka City and three adjacent areas. The case group comprised 840 patients undergoing surgery for a first diagnosis of colorectal cancer, while the control subjects were 833 residents who were selected in the community by two-stage random sampling. Past history of selected diseases, surgery and lifestyle factors were ascertained by in-person interview. Statistical adjustment was made for sex, 5-year age class, residence, smoking, alcohol drinking, physical activity, body mass index and parental history of colorectal cancer. Results: Overall, 74 case patients (9%) and 85 control subjects (10%) reported a prior history of colorectal polyps, and 50 cases (6%) and 64 controls (8%) had a history of colorectal polypectomy. The adjusted odds ratio associated with colorectal polypectomy was 0.71 (95% confidence interval [CI] 0.48-1.06) for the overall risk of colorectal cancer. The corresponding values for cancer of the proximal colon, distal colon, and rectum were 1.68 (95% CI 0.98-2.88), 0.71 (95% CI 0.41-1.26) and 0.24 (95% CI 0.11-0.52), respectively. Conclusions: The findings indicate that colorectal polypectomy in current practice confers a decreased risk of rectal cancer and possibly of distal colon cancer.

Original languageEnglish
Pages (from-to)597-602
Number of pages6
JournalJapanese journal of clinical oncology
Volume37
Issue number8
DOIs
Publication statusPublished - Aug 1 2007

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Colorectal Neoplasms
Confidence Intervals
Polyps
Colonic Neoplasms
Social Adjustment
Rectal Neoplasms
Rectum
Alcohol Drinking
Adenoma
Case-Control Studies
Life Style
Colon
Body Mass Index
Smoking
Odds Ratio
Interviews
Exercise

All Science Journal Classification (ASJC) codes

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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Colorectal polypectomy and risk of colorectal cancer by subsite : The Fukuoka colorectal cancer study. / Yoshida, Daigo; Kono, Suminori; Moore, Malcolm A.; Toyomura, Kengo; Nagano, Jun; Mizoue, Tetsuya; Mibu, Ryuichi; Tanaka, Masao; Kakeji, Yoshihiro; Maehara, Yoshihiko; Okamura, Takeshi; Ikejiri, Koji; Futami, Kitaroh; Yasunami, Yohichi; Maekawa, Takafumi; Takenaka, Kenji; Ichimiya, Hitoshi; Imaizumi, Nobutoshi.

In: Japanese journal of clinical oncology, Vol. 37, No. 8, 01.08.2007, p. 597-602.

Research output: Contribution to journalArticle

Yoshida, D, Kono, S, Moore, MA, Toyomura, K, Nagano, J, Mizoue, T, Mibu, R, Tanaka, M, Kakeji, Y, Maehara, Y, Okamura, T, Ikejiri, K, Futami, K, Yasunami, Y, Maekawa, T, Takenaka, K, Ichimiya, H & Imaizumi, N 2007, 'Colorectal polypectomy and risk of colorectal cancer by subsite: The Fukuoka colorectal cancer study', Japanese journal of clinical oncology, vol. 37, no. 8, pp. 597-602. https://doi.org/10.1093/jjco/hym065
Yoshida, Daigo ; Kono, Suminori ; Moore, Malcolm A. ; Toyomura, Kengo ; Nagano, Jun ; Mizoue, Tetsuya ; Mibu, Ryuichi ; Tanaka, Masao ; Kakeji, Yoshihiro ; Maehara, Yoshihiko ; Okamura, Takeshi ; Ikejiri, Koji ; Futami, Kitaroh ; Yasunami, Yohichi ; Maekawa, Takafumi ; Takenaka, Kenji ; Ichimiya, Hitoshi ; Imaizumi, Nobutoshi. / Colorectal polypectomy and risk of colorectal cancer by subsite : The Fukuoka colorectal cancer study. In: Japanese journal of clinical oncology. 2007 ; Vol. 37, No. 8. pp. 597-602.
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abstract = "Background: Colorectal adenomas are well-established precursor lesions for colorectal cancer and removal of polyps is deemed to reduce the risk of colorectal cancer. However, benefit of colorectal polypectomy in routine practice is still uncertain. We therefore investigated subsite-specific risks of colorectal cancer in relation to history of colorectal polypectomy in a case-control study. Methods: Both case patients and control subjects were residents aged 20-74 years in Fukuoka City and three adjacent areas. The case group comprised 840 patients undergoing surgery for a first diagnosis of colorectal cancer, while the control subjects were 833 residents who were selected in the community by two-stage random sampling. Past history of selected diseases, surgery and lifestyle factors were ascertained by in-person interview. Statistical adjustment was made for sex, 5-year age class, residence, smoking, alcohol drinking, physical activity, body mass index and parental history of colorectal cancer. Results: Overall, 74 case patients (9{\%}) and 85 control subjects (10{\%}) reported a prior history of colorectal polyps, and 50 cases (6{\%}) and 64 controls (8{\%}) had a history of colorectal polypectomy. The adjusted odds ratio associated with colorectal polypectomy was 0.71 (95{\%} confidence interval [CI] 0.48-1.06) for the overall risk of colorectal cancer. The corresponding values for cancer of the proximal colon, distal colon, and rectum were 1.68 (95{\%} CI 0.98-2.88), 0.71 (95{\%} CI 0.41-1.26) and 0.24 (95{\%} CI 0.11-0.52), respectively. Conclusions: The findings indicate that colorectal polypectomy in current practice confers a decreased risk of rectal cancer and possibly of distal colon cancer.",
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T1 - Colorectal polypectomy and risk of colorectal cancer by subsite

T2 - The Fukuoka colorectal cancer study

AU - Yoshida, Daigo

AU - Kono, Suminori

AU - Moore, Malcolm A.

AU - Toyomura, Kengo

AU - Nagano, Jun

AU - Mizoue, Tetsuya

AU - Mibu, Ryuichi

AU - Tanaka, Masao

AU - Kakeji, Yoshihiro

AU - Maehara, Yoshihiko

AU - Okamura, Takeshi

AU - Ikejiri, Koji

AU - Futami, Kitaroh

AU - Yasunami, Yohichi

AU - Maekawa, Takafumi

AU - Takenaka, Kenji

AU - Ichimiya, Hitoshi

AU - Imaizumi, Nobutoshi

PY - 2007/8/1

Y1 - 2007/8/1

N2 - Background: Colorectal adenomas are well-established precursor lesions for colorectal cancer and removal of polyps is deemed to reduce the risk of colorectal cancer. However, benefit of colorectal polypectomy in routine practice is still uncertain. We therefore investigated subsite-specific risks of colorectal cancer in relation to history of colorectal polypectomy in a case-control study. Methods: Both case patients and control subjects were residents aged 20-74 years in Fukuoka City and three adjacent areas. The case group comprised 840 patients undergoing surgery for a first diagnosis of colorectal cancer, while the control subjects were 833 residents who were selected in the community by two-stage random sampling. Past history of selected diseases, surgery and lifestyle factors were ascertained by in-person interview. Statistical adjustment was made for sex, 5-year age class, residence, smoking, alcohol drinking, physical activity, body mass index and parental history of colorectal cancer. Results: Overall, 74 case patients (9%) and 85 control subjects (10%) reported a prior history of colorectal polyps, and 50 cases (6%) and 64 controls (8%) had a history of colorectal polypectomy. The adjusted odds ratio associated with colorectal polypectomy was 0.71 (95% confidence interval [CI] 0.48-1.06) for the overall risk of colorectal cancer. The corresponding values for cancer of the proximal colon, distal colon, and rectum were 1.68 (95% CI 0.98-2.88), 0.71 (95% CI 0.41-1.26) and 0.24 (95% CI 0.11-0.52), respectively. Conclusions: The findings indicate that colorectal polypectomy in current practice confers a decreased risk of rectal cancer and possibly of distal colon cancer.

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