Combination chemotherapy with methotrexate and 5-fluorouracil and surgery for advanced gastric cancer with liver and lymph node metastases: A case report

D. Korenaga, F. Takesue, Y. Toh, S. Maekawa, T. Ikeda, K. Sugimachi

Research output: Contribution to journalArticle

Abstract

We report on a case of advanced gastric cancer with multiple liver metastasis and lymph node metastases in a 65-year-old Japanese man. He was treated with sequential intravenous administration of moderate-dose methotrexate (MTX) and 5-fluorouracil (5-FU) preoperatively. After eleven cycles of the combination chemotherapy, the findings of liver and lymph node metastases diminished dramatically and the tumor could be resected for a potential cure, using a total gastrectomy and combined hepatectomy. The resected specimen revealed a slightly elevated lesion and a somewhat shallow ulceration due to chemotherapy. Histologically, there was an infiltration of poorly differentiated adenocarcinomas with medullary structure in the muscularis mucosae with fibrous change. The liver was metastasized, but there was no evidence of lymph node metastasis. We believe that combination chemotherapy of MTX and 5-FU can be effective against gastric cancer.

Original languageEnglish
Pages (from-to)505-507
Number of pages3
JournalOncology reports
Volume2
Issue number4
DOIs
Publication statusPublished - 1995
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Combination chemotherapy with methotrexate and 5-fluorouracil and surgery for advanced gastric cancer with liver and lymph node metastases: A case report'. Together they form a unique fingerprint.

Cite this