Combination chemotherapy with methotrexate and 5-fluorouracil and surgery for advanced gastric cancer with liver and lymph node metastases

A case report

D. Korenaga, F. Takesue, Y. Toh, S. Maekawa, Tetsuo Ikeda, K. Sugimachi

Research output: Contribution to journalArticle

Abstract

We report on a case of advanced gastric cancer with multiple liver metastasis and lymph node metastases in a 65-year-old Japanese man. He was treated with sequential intravenous administration of moderate-dose methotrexate (MTX) and 5-fluorouracil (5-FU) preoperatively. After eleven cycles of the combination chemotherapy, the findings of liver and lymph node metastases diminished dramatically and the tumor could be resected for a potential cure, using a total gastrectomy and combined hepatectomy. The resected specimen revealed a slightly elevated lesion and a somewhat shallow ulceration due to chemotherapy. Histologically, there was an infiltration of poorly differentiated adenocarcinomas with medullary structure in the muscularis mucosae with fibrous change. The liver was metastasized, but there was no evidence of lymph node metastasis. We believe that combination chemotherapy of MTX and 5-FU can be effective against gastric cancer.

Original languageEnglish
Pages (from-to)505-507
Number of pages3
JournalOncology reports
Volume2
Issue number4
Publication statusPublished - Jan 1 1995

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Liver Neoplasms
Combination Drug Therapy
Methotrexate
Fluorouracil
Stomach Neoplasms
Lymph Nodes
Neoplasm Metastasis
Liver
Hepatectomy
Gastrectomy
Intravenous Administration
Mucous Membrane
Adenocarcinoma
Drug Therapy
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Combination chemotherapy with methotrexate and 5-fluorouracil and surgery for advanced gastric cancer with liver and lymph node metastases : A case report. / Korenaga, D.; Takesue, F.; Toh, Y.; Maekawa, S.; Ikeda, Tetsuo; Sugimachi, K.

In: Oncology reports, Vol. 2, No. 4, 01.01.1995, p. 505-507.

Research output: Contribution to journalArticle

Korenaga, D. ; Takesue, F. ; Toh, Y. ; Maekawa, S. ; Ikeda, Tetsuo ; Sugimachi, K. / Combination chemotherapy with methotrexate and 5-fluorouracil and surgery for advanced gastric cancer with liver and lymph node metastases : A case report. In: Oncology reports. 1995 ; Vol. 2, No. 4. pp. 505-507.
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