Combination of serum squamous cell carcinoma antigens 1 and 2 as potential diagnostic marker for sinonasal squamous cell carcinoma and inverted papilloma

Ryuji Yasumatsu, Takafumi Nakano, Masanobu Sato, Rina Jiroumaru, Kazuki Hashimoto, Ryunosuke Kogo, Takahiro Wakasaki, Torahiko Nakashima, Takashi Nakagawa

Research output: Contribution to journalArticle


Background: Differentiating inverted papilloma from squamous cell carcinoma (SCC) is sometimes difficult. We evaluated the clinical usefulness of serum SCCA1 and SCCA2 in the management of patients with inverted papilloma or SCC. Methods: Serum and tissue samples for the analysis of SCCA1, SCCA2, and SCC antigen were taken from 18 patients with sinonasal inverted papilloma and 23 cases with sinonasal SCC. The SCCA1, SCCA2, and SCC antigen levels were determined. Results: The serum SCCA1 concentration was significantly higher in the inverted papilloma group than in the SCC group, whereas the serum SCCA2 level was significantly higher in the SCC group than in the inverted papilloma group. Conclusion: Patients with sinonasal inverted papilloma predominantly express SCCA1 protein, whereas those with SCC predominantly express SCCA2. This suggests that combined measurements of both serum SCCA1 and SCCA2 concentrations can be very useful for distinguishing sinonasal inverted papilloma from SCC.

Original languageEnglish
Pages (from-to)2583-2589
Number of pages7
JournalHead and Neck
Issue number12
Publication statusPublished - Dec 2018


All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

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