Combination of serum squamous cell carcinoma antigens 1 and 2 as potential diagnostic marker for sinonasal squamous cell carcinoma and inverted papilloma

Ryuji Yasumatsu; Takafumi Nakano; Masanobu Sato; Rina Jiroumaru; Kazuki Hashimoto; Ryunosuke Kogo; Takahiro Wakasaki; Torahiko Nakashima; Takashi Nakagawa

doi:10.1002/hed.25351

Combination of serum squamous cell carcinoma antigens 1 and 2 as potential diagnostic marker for sinonasal squamous cell carcinoma and inverted papilloma

Ryuji Yasumatsu, Takafumi Nakano, Masanobu Sato, Rina Jiroumaru, Kazuki Hashimoto, Ryunosuke Kogo, Takahiro Wakasaki, Torahiko Nakashima, Takashi Nakagawa

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Background: Differentiating inverted papilloma from squamous cell carcinoma (SCC) is sometimes difficult. We evaluated the clinical usefulness of serum SCCA1 and SCCA2 in the management of patients with inverted papilloma or SCC. Methods: Serum and tissue samples for the analysis of SCCA1, SCCA2, and SCC antigen were taken from 18 patients with sinonasal inverted papilloma and 23 cases with sinonasal SCC. The SCCA1, SCCA2, and SCC antigen levels were determined. Results: The serum SCCA1 concentration was significantly higher in the inverted papilloma group than in the SCC group, whereas the serum SCCA2 level was significantly higher in the SCC group than in the inverted papilloma group. Conclusion: Patients with sinonasal inverted papilloma predominantly express SCCA1 protein, whereas those with SCC predominantly express SCCA2. This suggests that combined measurements of both serum SCCA1 and SCCA2 concentrations can be very useful for distinguishing sinonasal inverted papilloma from SCC.

Original language	English
Pages (from-to)	2583-2589
Number of pages	7
Journal	Head and Neck
Volume	40
Issue number	12
DOIs	https://doi.org/10.1002/hed.25351
Publication status	Published - Dec 2018

All Science Journal Classification (ASJC) codes

Otorhinolaryngology

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title = "Combination of serum squamous cell carcinoma antigens 1 and 2 as potential diagnostic marker for sinonasal squamous cell carcinoma and inverted papilloma",

abstract = "Background: Differentiating inverted papilloma from squamous cell carcinoma (SCC) is sometimes difficult. We evaluated the clinical usefulness of serum SCCA1 and SCCA2 in the management of patients with inverted papilloma or SCC. Methods: Serum and tissue samples for the analysis of SCCA1, SCCA2, and SCC antigen were taken from 18 patients with sinonasal inverted papilloma and 23 cases with sinonasal SCC. The SCCA1, SCCA2, and SCC antigen levels were determined. Results: The serum SCCA1 concentration was significantly higher in the inverted papilloma group than in the SCC group, whereas the serum SCCA2 level was significantly higher in the SCC group than in the inverted papilloma group. Conclusion: Patients with sinonasal inverted papilloma predominantly express SCCA1 protein, whereas those with SCC predominantly express SCCA2. This suggests that combined measurements of both serum SCCA1 and SCCA2 concentrations can be very useful for distinguishing sinonasal inverted papilloma from SCC.",

author = "Ryuji Yasumatsu and Takafumi Nakano and Masanobu Sato and Rina Jiroumaru and Kazuki Hashimoto and Ryunosuke Kogo and Takahiro Wakasaki and Torahiko Nakashima and Takashi Nakagawa",

year = "2018",

month = dec,

doi = "10.1002/hed.25351",

language = "English",

volume = "40",

pages = "2583--2589",

journal = "Head and Neck Surgery",

issn = "1043-3074",

publisher = "John Wiley and Sons Inc.",

number = "12",

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TY - JOUR

T1 - Combination of serum squamous cell carcinoma antigens 1 and 2 as potential diagnostic marker for sinonasal squamous cell carcinoma and inverted papilloma

AU - Yasumatsu, Ryuji

AU - Nakano, Takafumi

AU - Sato, Masanobu

AU - Jiroumaru, Rina

AU - Hashimoto, Kazuki

AU - Kogo, Ryunosuke

AU - Wakasaki, Takahiro

AU - Nakashima, Torahiko

AU - Nakagawa, Takashi

PY - 2018/12

Y1 - 2018/12

N2 - Background: Differentiating inverted papilloma from squamous cell carcinoma (SCC) is sometimes difficult. We evaluated the clinical usefulness of serum SCCA1 and SCCA2 in the management of patients with inverted papilloma or SCC. Methods: Serum and tissue samples for the analysis of SCCA1, SCCA2, and SCC antigen were taken from 18 patients with sinonasal inverted papilloma and 23 cases with sinonasal SCC. The SCCA1, SCCA2, and SCC antigen levels were determined. Results: The serum SCCA1 concentration was significantly higher in the inverted papilloma group than in the SCC group, whereas the serum SCCA2 level was significantly higher in the SCC group than in the inverted papilloma group. Conclusion: Patients with sinonasal inverted papilloma predominantly express SCCA1 protein, whereas those with SCC predominantly express SCCA2. This suggests that combined measurements of both serum SCCA1 and SCCA2 concentrations can be very useful for distinguishing sinonasal inverted papilloma from SCC.

AB - Background: Differentiating inverted papilloma from squamous cell carcinoma (SCC) is sometimes difficult. We evaluated the clinical usefulness of serum SCCA1 and SCCA2 in the management of patients with inverted papilloma or SCC. Methods: Serum and tissue samples for the analysis of SCCA1, SCCA2, and SCC antigen were taken from 18 patients with sinonasal inverted papilloma and 23 cases with sinonasal SCC. The SCCA1, SCCA2, and SCC antigen levels were determined. Results: The serum SCCA1 concentration was significantly higher in the inverted papilloma group than in the SCC group, whereas the serum SCCA2 level was significantly higher in the SCC group than in the inverted papilloma group. Conclusion: Patients with sinonasal inverted papilloma predominantly express SCCA1 protein, whereas those with SCC predominantly express SCCA2. This suggests that combined measurements of both serum SCCA1 and SCCA2 concentrations can be very useful for distinguishing sinonasal inverted papilloma from SCC.

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JO - Head and Neck Surgery

JF - Head and Neck Surgery

IS - 12

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Combination of serum squamous cell carcinoma antigens 1 and 2 as potential diagnostic marker for sinonasal squamous cell carcinoma and inverted papilloma

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