Combination therapy of resection and intraoperative radiation for patients with carcinomas of extrahepatic bile duct and ampulla of Vater: Prognostic advantage over resection alone?

Kenji Nakano, Kazuo Chijiiwa, Takayuki Toyonaga, Junji Ueda, Yuji Takamatsu, Masahiko Kimura, Katsumasa Nakamura, Koji Yamaguchi, Masao Tanaka

    Research output: Contribution to journalArticlepeer-review

    7 Citations (Scopus)

    Abstract

    Background/Aims: To investigate the therapeutic efficacy of intraoperative radiation for carcinomas of the bile duct and ampulla of Vater. Methodology: Postoperative morbidity, mortality and survival of patients undergoing surgical resection of ampullary cancer (n=19) and bile duct cancer (n=28) were retrospectively compared between two groups with and without intraoperative radiation. Results: Background items (age, gender, preoperative laboratory data, operative time and bleeding volume, tumor stage) did not differ significantly between the two groups. The predominant postoperative complication was leakage of pancreatic juice, which occurred in similar rates in both groups. No significant differences were noted in the 3-year survival rates between the resection plus intraoperative radiation group and resection alone group (60.0% (n=5) vs. 50.1% (n=13) for ampullary cancer; 0% (n=4) vs. 27.1% (n=24) for bile duct cancer, respectively). The main causes of recurrence were distant metastasis for ampullary cancer and microscopic residue of carcinoma for bile duct cancer. Conclusions: The combination of intraoperative radiation and resection may add no significant benefit to patients with ampullary and bile duct cancer when compared with resection alone.

    Original languageEnglish
    Pages (from-to)928-933
    Number of pages6
    JournalHepato-gastroenterology
    Volume50
    Issue number52
    Publication statusPublished - Jul 2003

    All Science Journal Classification (ASJC) codes

    • Hepatology
    • Gastroenterology

    Fingerprint Dive into the research topics of 'Combination therapy of resection and intraoperative radiation for patients with carcinomas of extrahepatic bile duct and ampulla of Vater: Prognostic advantage over resection alone?'. Together they form a unique fingerprint.

    Cite this