Combined antibacterial effects of between meropenem and vancomycin, teicoplanin, linezolid, or arbekacin in methicillin-resistant Staphylococcus aureus

Noriko Tsuchimochi, Yujiro Uchida, Yoji Nagasaki, Yoshihiro Eriguchi, Yoriko Maehara, Masako Kadowaki, Nobuyuki Shimono

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In vitro interaction between meropenem(MEPM) and vancomycin(VCM), teicoplanin(TEIC), linezolid (LZD) , or arbekacin(ABK) was studied using the checkerboard technique in 207 clinical isolates of methicillin-resistant Staphylococcus aureus(MRSA) (MIC of MEPM ≧32). Of 207 strains, synergistic or additive action was observed in all strains by combination of MEPM and VCM or TEIC. A combination of MEPM and LZD or ABK showed synergistic or additive 196 strains (94.7%) and 159 strains (76.8%). Antagonism was not observed in any combination of MEPM and VCM, TEIC, or LZD, but 22 strains (10.6%) exhibited antagonism in combination with MEPM and ABK. It is thus important to know both the susceptibility of anti-MRSA agents alone and the combined effects of agents.

Original languageEnglish
Pages (from-to)363-367
Number of pages5
JournalJapanese Journal of Chemotherapy
Volume55
Issue number5
Publication statusPublished - Sep 2007

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

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