Combined effects of sesamin with alpha-tocopherol or tocotrienols on lipid and immune indices in Brown-Norway rats

Jiongyan Gu, Akira Tsujita, Yoko Wakizono, Koji Yamada, Michihiro Sugano

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

This study was designed to compare the combined effects of sesamin with α-tocopherol (Toc) or tocotrienols (T-3) on fatty acid composition, leukotriene production, and immune indices in immunosensitive Brown-Norway rats. Diets containing Toc and T-3 (both 0.2%) alone or in combination with sesamin (0.2%) were given for 3 weeks. When rats were fed Toc or T-3 alone, there were no significant differences in liver lipid concentration and polyunsaturated fatty acid composition, or splenic leukotriene production. Feeding T-3 alone reduced the liver thiobarbituric acid (TBA) values and increased CD4+/CD8+ ratio of mesenteric lymph node (MLN) T-lymphocytes significantly compared to the corresponding Toc group. However, when given together with sesamin, Toc significantly reduced 18:2n-6, 20:4n-6 levels of liver phosphatidylcholine, splenic CD8+ T-cell subsets, IgA level, and serum IgM level, while it increased the concentration of liver phospholipid and triglyceride, CD4+/CD8+ ratio, and splenic IgG and IgM levels. The combination of T-3 with sesamin showed a similar effect but to a more marked extent in addition to the reduction of the blood TBA values and serum IgE level and the increase in IgG level in MLN lymphocytes. These results indicate that simultaneous administration of Toc or T-3 with sesamin was more effective than individually in modulating immune indices, particularly in the latter combination.

Original languageEnglish
Pages (from-to)339-350
Number of pages12
JournalNutrition Research
Volume17
Issue number2
DOIs
Publication statusPublished - Feb 1 1997

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Tocopherols
alpha-Tocopherol
Lipids
CD4-CD8 Ratio
Leukotrienes
Liver
Immunoglobulin M
Immunoglobulin G
Lymph Nodes
Tocotrienols
T-Lymphocyte Subsets
Serum
Phosphatidylcholines
Unsaturated Fatty Acids
Immunoglobulin A
Immunoglobulin E
alpha tocotrienol
sesamin
Phospholipids
Triglycerides

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

Cite this

Combined effects of sesamin with alpha-tocopherol or tocotrienols on lipid and immune indices in Brown-Norway rats. / Gu, Jiongyan; Tsujita, Akira; Wakizono, Yoko; Yamada, Koji; Sugano, Michihiro.

In: Nutrition Research, Vol. 17, No. 2, 01.02.1997, p. 339-350.

Research output: Contribution to journalArticle

Gu, Jiongyan ; Tsujita, Akira ; Wakizono, Yoko ; Yamada, Koji ; Sugano, Michihiro. / Combined effects of sesamin with alpha-tocopherol or tocotrienols on lipid and immune indices in Brown-Norway rats. In: Nutrition Research. 1997 ; Vol. 17, No. 2. pp. 339-350.
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