Common duct carcinoma and obstruction in female hamsters treated with af-nitrosobis(2-oxopropyl)amine and/or cholecystectomy

T. Kamano, A. Katami, J. Tamura, N. Azuma, Y. Mori, T. Makino, K. Mizumoto, Y. Konishi

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Detailed histologic observations were performed on the head of the pancreas of hamsters treated with 10 mg/kg body weight /V-nitrosobis(2-oxo-propyl)amine (BOP) once a week for 6 weeks with or without cholecystectomy. Cholecystectomy was performed 5 weeks before starting BOP initiation. The incidence of head cancers was 100% and cholecystectomy did not affect pancreatic carcinogenesis by BOP. Common bile duct dilatation was produced by advanced pancreatic head carcinomas and microadenocarcinomas in common duct. Micro-adenocarcinomas were not macroscopically detected since the tumors were located in the lumen of common duct.

Original languageEnglish
Pages (from-to)688-693
Number of pages6
JournalPancreas
Volume2
Issue number6
DOIs
Publication statusPublished - Nov 1987
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

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