Comparable effects of adrenalectomy and C fiber depletion on delayed-type hypersensitivity in rats

Toshihiko Katafuchi, Tetsuya Kondo, Tetsuro Hori

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective: To determine the influence of the hypothalamic-pituitary-adrenal (HPA) axis and sensory C fibers on cell-mediated immunity, the time course of allergic contact dermatitis (ACD) was examined in normal, adrenalectomized (ADX) and capsaicin (CAP)-treated rats. Methods: Five days after sensitization with 2,4-dinitro-1-fluorobenzene (DNFB) onto the back, rats were challenged with DNFB on the pinna. ADX or CAP treatment was performed a week before the sensitization. Results: Ear swelling in normal rats reached a peak 24 h after the challenge and subsided gradually to about half of this peak 72 h afterwards. Plasma ACTH levels increased about 9 times more than those of nonsensitized rats 72 h after the challenge. ADX rats, in which the plasma corticosterone level was significantly lower than that in sham-operated animals, exhibited more rapid development of ACD, which reached a peak 12 h after the challenge. However, the swelling returned to about half of the maximum within 48 h. In CAP-treated rats, ACD reached a peak 6 h after the challenge and recovered quickly as in ADX rats. Plasma ACTH levels in CAP-treated rats were significantly lower than those in vehicle-treated rats. Conclusions: The rapid development of and recovery from ACD in ADX and CAP-treated rats, both of which showed suppression of the HPA axis, indicated a biphasic action of the HPA axis on ACD, i.e. inhibitory in the early phase but augmentative in the late phase of ACD.

Original languageEnglish
Pages (from-to)157-162
Number of pages6
JournalNeuroImmunoModulation
Volume9
Issue number3
DOIs
Publication statusPublished - Dec 1 2001

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Unmyelinated Nerve Fibers
Adrenalectomy
Delayed Hypersensitivity
Allergic Contact Dermatitis
Capsaicin
Fluorobenzenes
Adrenocorticotropic Hormone
Corticosterone
Cellular Immunity
Ear

All Science Journal Classification (ASJC) codes

  • Immunology
  • Endocrinology
  • Neurology
  • Endocrine and Autonomic Systems

Cite this

Comparable effects of adrenalectomy and C fiber depletion on delayed-type hypersensitivity in rats. / Katafuchi, Toshihiko; Kondo, Tetsuya; Hori, Tetsuro.

In: NeuroImmunoModulation, Vol. 9, No. 3, 01.12.2001, p. 157-162.

Research output: Contribution to journalArticle

Katafuchi, Toshihiko ; Kondo, Tetsuya ; Hori, Tetsuro. / Comparable effects of adrenalectomy and C fiber depletion on delayed-type hypersensitivity in rats. In: NeuroImmunoModulation. 2001 ; Vol. 9, No. 3. pp. 157-162.
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