Comparative adherence to antidepressant drugs in a non-psychiatric outpatient clinic setting in Japan

Hideyo Sugahara, Shoji Tokunaga, Tetsuya Kondo, Mariko Akamine, Kouichi Yoshimasu, Kanichiro Fujisawa, Katsuyuki Fukudome, Yoshio Kanemitsu, Chiharu Kubo

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Premature discontinuation of antidepressant treatment is associated with an increased risk of relapse. There is, however, little evidence concerning comparative discontinuation rates of different classes of antidepressants such as tricyclic antidepressants, selective serotonin reuptake inhibitors, and atypical antidepressants such as sulpiride. We have studied the adherence to different antidepressant treatments during the early treatment phase. Over a 10-month period, a total of 265 outpatients, who were prescribed one or more antidepressants in a psychosomatic medical department of a Japanese University Hospital, were enrolled for study. The subjects were generally suffering from mild to moderate depression. The adherence to antidepressant medication was observed during the initial 13 weeks of treatment. The data were analysed using Kaplan-Meier method and Cox proportional hazards model. The overall adherence to antidepressants over the initial 13 weeks was 66.8%. Among the antidepressants used, the adherence to sulpiride was the best (87.6%), followed by maprotiline (76.6%) and clomipramine (66.9%). The adherence to sulpiride was statistically significantly greater than the other antidepressants employed. It is suggested that sulpiride is particularly suitable for use in the psychosomatic medical setting in Japan and probably elsewhere.

Original languageEnglish
Pages (from-to)57-62
Number of pages6
JournalPrimary Care and Community Psychiatry
Volume10
Issue number2
DOIs
Publication statusPublished - Dec 12 2005

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Ambulatory Care Facilities
Antidepressive Agents
Japan
Sulpiride
Second-Generation Antidepressive Agents
Maprotiline
Clomipramine
Tricyclic Antidepressive Agents
Serotonin Uptake Inhibitors
Therapeutics
Proportional Hazards Models
Outpatients
Recurrence

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health
  • Psychiatry and Mental health

Cite this

Comparative adherence to antidepressant drugs in a non-psychiatric outpatient clinic setting in Japan. / Sugahara, Hideyo; Tokunaga, Shoji; Kondo, Tetsuya; Akamine, Mariko; Yoshimasu, Kouichi; Fujisawa, Kanichiro; Fukudome, Katsuyuki; Kanemitsu, Yoshio; Kubo, Chiharu.

In: Primary Care and Community Psychiatry, Vol. 10, No. 2, 12.12.2005, p. 57-62.

Research output: Contribution to journalArticle

Sugahara, H, Tokunaga, S, Kondo, T, Akamine, M, Yoshimasu, K, Fujisawa, K, Fukudome, K, Kanemitsu, Y & Kubo, C 2005, 'Comparative adherence to antidepressant drugs in a non-psychiatric outpatient clinic setting in Japan', Primary Care and Community Psychiatry, vol. 10, no. 2, pp. 57-62. https://doi.org/10.1185/135525705X40418
Sugahara, Hideyo ; Tokunaga, Shoji ; Kondo, Tetsuya ; Akamine, Mariko ; Yoshimasu, Kouichi ; Fujisawa, Kanichiro ; Fukudome, Katsuyuki ; Kanemitsu, Yoshio ; Kubo, Chiharu. / Comparative adherence to antidepressant drugs in a non-psychiatric outpatient clinic setting in Japan. In: Primary Care and Community Psychiatry. 2005 ; Vol. 10, No. 2. pp. 57-62.
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