TY - JOUR
T1 - Comparative chronic toxicity, including tumorigenicity, of gallium arsenide and arsenic trioxide intratracheally instilled into hamsters
AU - Ohyama, Shiro
AU - Ishinishi, Noburu
AU - Hisanaga, Akira
AU - Yamamoto, Akiyo
PY - 1988
Y1 - 1988
N2 - Chronic toxicity, including tumorigenicity, of gallium arsenide (GaAs) and arsenic trioxide (As2O3) were studied using Syrian golden hamsters given intermittent intratracheal instillations. GaAs particles (0.25 mg × 15 times/animal) were likely to produce relatively severe lung damage and the survival of the animals was shortened significantly compared with a control group. The tumor incidence of each group examined was GaAs (3.3%), As2O3 (3.3%) respectively, at a dose of 3.75 mg total metal given during 15 weeks. In this experiment, both arsenic trioxide and gallium arsenide had no apparent carcinogenicity or tumorigenicity.
AB - Chronic toxicity, including tumorigenicity, of gallium arsenide (GaAs) and arsenic trioxide (As2O3) were studied using Syrian golden hamsters given intermittent intratracheal instillations. GaAs particles (0.25 mg × 15 times/animal) were likely to produce relatively severe lung damage and the survival of the animals was shortened significantly compared with a control group. The tumor incidence of each group examined was GaAs (3.3%), As2O3 (3.3%) respectively, at a dose of 3.75 mg total metal given during 15 weeks. In this experiment, both arsenic trioxide and gallium arsenide had no apparent carcinogenicity or tumorigenicity.
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U2 - 10.1002/aoc.590020409
DO - 10.1002/aoc.590020409
M3 - Article
AN - SCOPUS:84990496376
VL - 2
SP - 333
EP - 337
JO - Applied Organometallic Chemistry
JF - Applied Organometallic Chemistry
SN - 0268-2605
IS - 4
ER -