Comparative chronic toxicity, including tumorigenicity, of gallium arsenide and arsenic trioxide intratracheally instilled into hamsters

Shiro Ohyama, Noburu Ishinishi, Akira Hisanaga, Akiyo Yamamoto

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

Chronic toxicity, including tumorigenicity, of gallium arsenide (GaAs) and arsenic trioxide (As2O3) were studied using Syrian golden hamsters given intermittent intratracheal instillations. GaAs particles (0.25 mg × 15 times/animal) were likely to produce relatively severe lung damage and the survival of the animals was shortened significantly compared with a control group. The tumor incidence of each group examined was GaAs (3.3%), As2O3 (3.3%) respectively, at a dose of 3.75 mg total metal given during 15 weeks. In this experiment, both arsenic trioxide and gallium arsenide had no apparent carcinogenicity or tumorigenicity.

Original languageEnglish
Pages (from-to)333-337
Number of pages5
JournalApplied Organometallic Chemistry
Volume2
Issue number4
DOIs
Publication statusPublished - 1988

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Inorganic Chemistry

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