Comparative study of PEG and PEGylated dendrimers in their eutectic mixtures with water analyzed using X-ray diffraction and infrared spectroscopy

Chie Kojima, Yasuhito Suzuki, Yuka Ikemoto, Masaru Tanaka, Akikazu Matsumoto

Research output: Contribution to journalArticlepeer-review

Abstract

It has been reported that the hydration state of biocompatible polymers, such as poly(ethylene glycol) (PEG), affects their bioinertness. PEGylated dendrimers have been studied for use as drug carriers. In our previous study, the hydration behaviors of PEG and PEGylated dendrimers were analyzed using differential scanning calorimetry (DSC) to investigate the relationship between hydration and in vivo behaviors. In this study, the hydration behaviors of PEG and PEGylated dendrimer were analyzed using X-ray diffraction (XRD) and infrared (IR) spectroscopy. According to the XRD analysis, ice was formed and melted in the PEG/water mixture with a 20% water content below 0 °C during the heating process; however, PEG crystals were formed in the PEG/water mixture containing 70% water. The XRD and IR results of the PEGylated dendrimer/water mixture were similar to those of the PEG/water system containing 70% water. Our IR spectral studies indicated that the hydration state of the PEGylated dendrimer was different from that of PEG containing 20% water. These results suggested that a comprehensive study is important for the analysis of such eutectic mixtures of PEG compounds and water.

Original languageEnglish
JournalPolymer Journal
DOIs
Publication statusAccepted/In press - 2022

All Science Journal Classification (ASJC) codes

  • Polymers and Plastics
  • Materials Chemistry

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