Comparative study on the carcinogenicity of N-nitrosodiethylamine, N-nitrosodhnethylamine, N-nitrosomorpholine, N-nitrosopyrrolidine and N-nitrosodi-N-propylamine to the lung of syrian golden hamsters following intermittent instillations to the trachea

Noburu Ishinishi, Akiyo Tanaka, Akira Hisanaga, Takeo Inamasu, Miyuki Hirata

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

N-Nitrosodiethylamine (NDEA), N-nitrosodimethylamine (NDMA), N-mtrosomorpholine (NMOR), N-nitrosopyrroli dine (NPYR) and N-nitrosodi-N-propylainine (NDPA) were instilled into the lungs of male Syrian golden hamsters by intratracheal instillatlons once a week for 15 weeks. The total doses given were 1.5 mg of each drug. As a control, hamsters were treated with the vehicle, phosphate buffer solution. During the total lifespan, tumor incidence rates in the respiratory organs were 100% in the NDEA group, 6% in the NDMA group, 43% in the NMOR group, 0% in the NPYR group, 72% in the NDPA group and 4% in the control group. The incidence rates in the liver were 19% in the NDMA group and 4% in the NPYR group. No liver tumors developed in the other groups. The carcinogenic potencies of these N-nitroso compounds to the respiratory organs was provisionally estimated to be in the following order: NDEA > NDPA> NMOR > NDMA ≒NPYR, at the 1.5 mg dosage level. However, the difference in the rates of tumor incidence between the NDMA or NPYR group and the control group was not significant.

Original languageEnglish
Pages (from-to)947-950
Number of pages4
JournalCarcinogenesis
Volume9
Issue number6
DOIs
Publication statusPublished - Jun 1 1988

All Science Journal Classification (ASJC) codes

  • Cancer Research

Fingerprint Dive into the research topics of 'Comparative study on the carcinogenicity of N-nitrosodiethylamine, N-nitrosodhnethylamine, N-nitrosomorpholine, N-nitrosopyrrolidine and N-nitrosodi-N-propylamine to the lung of syrian golden hamsters following intermittent instillations to the trachea'. Together they form a unique fingerprint.

  • Cite this