Comparison between Dietary Soybean Protein and Casein of the Inhibiting Effect on Atherogenesis in the Thoracic Aorta of Hypercholesterolemic (ExHC) Rats Treated with Experimental Hypervitamin D

Masanobu Sakono; Toshihiko Fukuyama; Wei Hua Ni; Koji Nagao; Hyang Ran Ju; Masao Sato; Noriyuki Sakata; Hisao Iwamoto; Katsumi Imaizumi

doi:10.1271/bbb.61.514

Comparison between Dietary Soybean Protein and Casein of the Inhibiting Effect on Atherogenesis in the Thoracic Aorta of Hypercholesterolemic (ExHC) Rats Treated with Experimental Hypervitamin D

Masanobu Sakono, Toshihiko Fukuyama, Wei Hua Ni, Koji Nagao, Hyang Ran Ju, Masao Sato, Noriyuki Sakata, Hisao Iwamoto, Katsumi Imaizumi

Food Science and Biotechnology

Research output: Contribution to journal › Article

7 Citations (Scopus)

Abstract

Atherosclerotic lesions of the thoracic aorta were induced in exogenously hypercholesterolemic (ExHC) rats by treating initially with hypervitamin D₂ and subsequently feeding on hypercholesterolemic diets for 180 days. Dietary soybean protein, in comparison with casein, substantially decreased the degree of atherosclerotic lesions, which was evaluated by intimai thickening, although with a similar topographical distribution. The casein-fed rats tended to maintain a high concentration of serum cholesterol, particularly in triacylglycerol-rich lipoproteins. The concentrations of apo A-I and TBARS in the serum was comparable between the dietary protein groups. The data suggest that dietary soybean protein, compared to casein, produced lipoproteins which were less atherosclerotic by partitioning cholesterol in the triacylglycerol-poor lipoproteins.

Original language	English
Pages (from-to)	514-519
Number of pages	6
Journal	Bioscience, Biotechnology and Biochemistry
Volume	61
Issue number	3
DOIs	https://doi.org/10.1271/bbb.61.514
Publication status	Published - Jan 1 1997

All Science Journal Classification (ASJC) codes

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

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Sakono, M., Fukuyama, T., Ni, W. H., Nagao, K., Ju, H. R., Sato, M., Sakata, N., Iwamoto, H., & Imaizumi, K. (1997). Comparison between Dietary Soybean Protein and Casein of the Inhibiting Effect on Atherogenesis in the Thoracic Aorta of Hypercholesterolemic (ExHC) Rats Treated with Experimental Hypervitamin D. Bioscience, Biotechnology and Biochemistry, 61(3), 514-519. https://doi.org/10.1271/bbb.61.514

Comparison between Dietary Soybean Protein and Casein of the Inhibiting Effect on Atherogenesis in the Thoracic Aorta of Hypercholesterolemic (ExHC) Rats Treated with Experimental Hypervitamin D. / Sakono, Masanobu; Fukuyama, Toshihiko; Ni, Wei Hua; Nagao, Koji; Ju, Hyang Ran; Sato, Masao; Sakata, Noriyuki; Iwamoto, Hisao; Imaizumi, Katsumi.

In: Bioscience, Biotechnology and Biochemistry, Vol. 61, No. 3, 01.01.1997, p. 514-519.

Research output: Contribution to journal › Article

Sakono, M, Fukuyama, T, Ni, WH, Nagao, K, Ju, HR, Sato, M, Sakata, N, Iwamoto, H & Imaizumi, K 1997, 'Comparison between Dietary Soybean Protein and Casein of the Inhibiting Effect on Atherogenesis in the Thoracic Aorta of Hypercholesterolemic (ExHC) Rats Treated with Experimental Hypervitamin D', Bioscience, Biotechnology and Biochemistry, vol. 61, no. 3, pp. 514-519. https://doi.org/10.1271/bbb.61.514

Sakono, Masanobu ; Fukuyama, Toshihiko ; Ni, Wei Hua ; Nagao, Koji ; Ju, Hyang Ran ; Sato, Masao ; Sakata, Noriyuki ; Iwamoto, Hisao ; Imaizumi, Katsumi. / Comparison between Dietary Soybean Protein and Casein of the Inhibiting Effect on Atherogenesis in the Thoracic Aorta of Hypercholesterolemic (ExHC) Rats Treated with Experimental Hypervitamin D. In: Bioscience, Biotechnology and Biochemistry. 1997 ; Vol. 61, No. 3. pp. 514-519.

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abstract = "Atherosclerotic lesions of the thoracic aorta were induced in exogenously hypercholesterolemic (ExHC) rats by treating initially with hypervitamin D2 and subsequently feeding on hypercholesterolemic diets for 180 days. Dietary soybean protein, in comparison with casein, substantially decreased the degree of atherosclerotic lesions, which was evaluated by intimai thickening, although with a similar topographical distribution. The casein-fed rats tended to maintain a high concentration of serum cholesterol, particularly in triacylglycerol-rich lipoproteins. The concentrations of apo A-I and TBARS in the serum was comparable between the dietary protein groups. The data suggest that dietary soybean protein, compared to casein, produced lipoproteins which were less atherosclerotic by partitioning cholesterol in the triacylglycerol-poor lipoproteins.",

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AU - Ni, Wei Hua

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