Comparison between Dietary Soybean Protein and Casein of the Inhibiting Effect on Atherogenesis in the Thoracic Aorta of Hypercholesterolemic (ExHC) Rats Treated with Experimental Hypervitamin D

Masanobu Sakono, Toshihiko Fukuyama, Wei Hua Ni, Koji Nagao, Hyang Ran Ju, Masao Sato, Noriyuki Sakata, Hisao Iwamoto, Katsumi Imaizumi

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Atherosclerotic lesions of the thoracic aorta were induced in exogenously hypercholesterolemic (ExHC) rats by treating initially with hypervitamin D2 and subsequently feeding on hypercholesterolemic diets for 180 days. Dietary soybean protein, in comparison with casein, substantially decreased the degree of atherosclerotic lesions, which was evaluated by intimai thickening, although with a similar topographical distribution. The casein-fed rats tended to maintain a high concentration of serum cholesterol, particularly in triacylglycerol-rich lipoproteins. The concentrations of apo A-I and TBARS in the serum was comparable between the dietary protein groups. The data suggest that dietary soybean protein, compared to casein, produced lipoproteins which were less atherosclerotic by partitioning cholesterol in the triacylglycerol-poor lipoproteins.

Original languageEnglish
Pages (from-to)514-519
Number of pages6
JournalBioscience, Biotechnology and Biochemistry
Volume61
Issue number3
DOIs
Publication statusPublished - Jan 1 1997

Fingerprint

Soybean Proteins
Caseins
Thoracic Aorta
Lipoproteins
Rats
Atherosclerosis
Triglycerides
Cholesterol
Dietary Proteins
Apolipoprotein A-I
Nutrition
Serum
Diet

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

Cite this

Comparison between Dietary Soybean Protein and Casein of the Inhibiting Effect on Atherogenesis in the Thoracic Aorta of Hypercholesterolemic (ExHC) Rats Treated with Experimental Hypervitamin D. / Sakono, Masanobu; Fukuyama, Toshihiko; Ni, Wei Hua; Nagao, Koji; Ju, Hyang Ran; Sato, Masao; Sakata, Noriyuki; Iwamoto, Hisao; Imaizumi, Katsumi.

In: Bioscience, Biotechnology and Biochemistry, Vol. 61, No. 3, 01.01.1997, p. 514-519.

Research output: Contribution to journalArticle

Sakono, Masanobu ; Fukuyama, Toshihiko ; Ni, Wei Hua ; Nagao, Koji ; Ju, Hyang Ran ; Sato, Masao ; Sakata, Noriyuki ; Iwamoto, Hisao ; Imaizumi, Katsumi. / Comparison between Dietary Soybean Protein and Casein of the Inhibiting Effect on Atherogenesis in the Thoracic Aorta of Hypercholesterolemic (ExHC) Rats Treated with Experimental Hypervitamin D. In: Bioscience, Biotechnology and Biochemistry. 1997 ; Vol. 61, No. 3. pp. 514-519.
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