Abstract
Atherosclerotic lesions of the thoracic aorta were induced in exogenously hypercholesterolemic (ExHC) rats by treating initially with hypervitamin D2 and subsequently feeding on hypercholesterolemic diets for 180 days. Dietary soybean protein, in comparison with casein, substantially decreased the degree of atherosclerotic lesions, which was evaluated by intimai thickening, although with a similar topographical distribution. The casein-fed rats tended to maintain a high concentration of serum cholesterol, particularly in triacylglycerol-rich lipoproteins. The concentrations of apo A-I and TBARS in the serum was comparable between the dietary protein groups. The data suggest that dietary soybean protein, compared to casein, produced lipoproteins which were less atherosclerotic by partitioning cholesterol in the triacylglycerol-poor lipoproteins.
| Original language | English |
|---|---|
| Pages (from-to) | 514-519 |
| Number of pages | 6 |
| Journal | Bioscience, Biotechnology and Biochemistry |
| Volume | 61 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Jan 1 1997 |
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All Science Journal Classification (ASJC) codes
- Biotechnology
- Analytical Chemistry
- Biochemistry
- Applied Microbiology and Biotechnology
- Molecular Biology
- Organic Chemistry
Cite this
Comparison between Dietary Soybean Protein and Casein of the Inhibiting Effect on Atherogenesis in the Thoracic Aorta of Hypercholesterolemic (ExHC) Rats Treated with Experimental Hypervitamin D. / Sakono, Masanobu; Fukuyama, Toshihiko; Ni, Wei Hua; Nagao, Koji; Ju, Hyang Ran; Sato, Masao; Sakata, Noriyuki; Iwamoto, Hisao; Imaizumi, Katsumi.
In: Bioscience, Biotechnology and Biochemistry, Vol. 61, No. 3, 01.01.1997, p. 514-519.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Comparison between Dietary Soybean Protein and Casein of the Inhibiting Effect on Atherogenesis in the Thoracic Aorta of Hypercholesterolemic (ExHC) Rats Treated with Experimental Hypervitamin D
AU - Sakono, Masanobu
AU - Fukuyama, Toshihiko
AU - Ni, Wei Hua
AU - Nagao, Koji
AU - Ju, Hyang Ran
AU - Sato, Masao
AU - Sakata, Noriyuki
AU - Iwamoto, Hisao
AU - Imaizumi, Katsumi
PY - 1997/1/1
Y1 - 1997/1/1
N2 - Atherosclerotic lesions of the thoracic aorta were induced in exogenously hypercholesterolemic (ExHC) rats by treating initially with hypervitamin D2 and subsequently feeding on hypercholesterolemic diets for 180 days. Dietary soybean protein, in comparison with casein, substantially decreased the degree of atherosclerotic lesions, which was evaluated by intimai thickening, although with a similar topographical distribution. The casein-fed rats tended to maintain a high concentration of serum cholesterol, particularly in triacylglycerol-rich lipoproteins. The concentrations of apo A-I and TBARS in the serum was comparable between the dietary protein groups. The data suggest that dietary soybean protein, compared to casein, produced lipoproteins which were less atherosclerotic by partitioning cholesterol in the triacylglycerol-poor lipoproteins.
AB - Atherosclerotic lesions of the thoracic aorta were induced in exogenously hypercholesterolemic (ExHC) rats by treating initially with hypervitamin D2 and subsequently feeding on hypercholesterolemic diets for 180 days. Dietary soybean protein, in comparison with casein, substantially decreased the degree of atherosclerotic lesions, which was evaluated by intimai thickening, although with a similar topographical distribution. The casein-fed rats tended to maintain a high concentration of serum cholesterol, particularly in triacylglycerol-rich lipoproteins. The concentrations of apo A-I and TBARS in the serum was comparable between the dietary protein groups. The data suggest that dietary soybean protein, compared to casein, produced lipoproteins which were less atherosclerotic by partitioning cholesterol in the triacylglycerol-poor lipoproteins.
UR - http://www.scopus.com/inward/record.url?scp=0031106416&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031106416&partnerID=8YFLogxK
U2 - 10.1271/bbb.61.514
DO - 10.1271/bbb.61.514
M3 - Article
C2 - 9095554
AN - SCOPUS:0031106416
VL - 61
SP - 514
EP - 519
JO - Bioscience, Biotechnology and Biochemistry
JF - Bioscience, Biotechnology and Biochemistry
SN - 0916-8451
IS - 3
ER -