Comparison of biliary atresia with and without intracranial hemorrhage

Yoshiaki Takahashi, Toshiharu Matsuura, Koichiro Yoshimaru, Yusuke Yanagi, Makoto Hayashida, Tomoaki Taguchi

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Abstract

Background/Purpose: Intracranial hemorrhage (ICH) is a severe complication of biliary atresia (BA). We aimed to compare the clinical data of BA patients with and without ICH. Methods: Sixty-three BA patients who underwent Kasai portoenterostomy were included in this study. We retrospectively reviewed their clinical records, and compared the ICH and non-ICH groups. Results: ICH occurred in seven patients (11.1%). The patients with ICH were significantly older at the time of Kasai portoenterostomy (median age: 90.0 vs 65.5 days). The hepatobiliary enzyme levels of the patients with ICH were significantly lower in comparison to the patients without ICH (T-Bil 6.7 vs 9.8 mg/dl; AST 95 vs 194 U/L; ALT 44 vs 114 U/L). On the other hand, the coagulation test values of the patients with ICH were significantly higher in comparison to the patients without ICH (PT 50.0 vs 12.4 s; APTT 200.0 vs 36.9 s). Although the survival rates did not differ to a statistically significant extent, persistent neurological sequelae occurred in two patients in the ICH group. Conclusions: The hepatobiliary enzyme levels of the patients with ICH were significantly lower than those without ICH. However, coagulopathy was found to be significantly more progressive in patients with ICH. Levels of Evidence: Level III.

Original languageEnglish
Pages (from-to)2245-2249
Number of pages5
JournalJournal of Pediatric Surgery
Volume53
Issue number11
DOIs
Publication statusPublished - Nov 1 2018

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Biliary Atresia
Intracranial Hemorrhages
Enzymes

All Science Journal Classification (ASJC) codes

  • Surgery
  • Pediatrics, Perinatology, and Child Health

Cite this

Comparison of biliary atresia with and without intracranial hemorrhage. / Takahashi, Yoshiaki; Matsuura, Toshiharu; Yoshimaru, Koichiro; Yanagi, Yusuke; Hayashida, Makoto; Taguchi, Tomoaki.

In: Journal of Pediatric Surgery, Vol. 53, No. 11, 01.11.2018, p. 2245-2249.

Research output: Contribution to journalArticle

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AU - Taguchi, Tomoaki

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