Comparison of carbon-ion passive and scanning irradiation for pancreatic cancer

Miho Shiomi, Shinichiro Mori, Makoto Shinoto, Yuko Nakayama, Tadashi Kamada, Shigeru Yamada

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Purpose To compare carbon-ion beam dose distribution between passive and scanning radiation therapies for locally advanced pancreatic cancer. Materials and methods Thirteen pancreatic cancer patients were included in this study. Four types of treatment planning with respiratory gating were calculated for each patient: a four-field box with passive irradiation (Plan 1), scanning irradiation (Plan 2), a three-field (150°, 180° and 210°) protocol with passive irradiation (Plan 3), and scanning irradiation (Plan 4). The irradiation plans each delivered 55.2 Gy (RBE) to the planning target volume (PTV) and were compared with respect to doses to the PTV and organs at risk (OARs). Results Plan 3 exceeded the dose assessment metrics to the spinal cord. Scanning irradiation plans (Plan 2 and, particularly, Plan 4) offered significantly reduced dosage to the stomach and the duodenum compared with passive irradiation. Conclusion Three-field oblique scanning irradiation for pancreatic cancer has the potential to reduce gastrointestinal exposure and influence of peristalsis on dose distribution.

Original languageEnglish
Pages (from-to)326-330
Number of pages5
JournalRadiotherapy and Oncology
Volume119
Issue number2
DOIs
Publication statusPublished - May 1 2016

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Pancreatic Neoplasms
Carbon
Ions
Organs at Risk
Peristalsis
Duodenum
Spinal Cord
Stomach
Radiotherapy
Therapeutics

All Science Journal Classification (ASJC) codes

  • Hematology
  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

Shiomi, M., Mori, S., Shinoto, M., Nakayama, Y., Kamada, T., & Yamada, S. (2016). Comparison of carbon-ion passive and scanning irradiation for pancreatic cancer. Radiotherapy and Oncology, 119(2), 326-330. https://doi.org/10.1016/j.radonc.2016.04.026

Comparison of carbon-ion passive and scanning irradiation for pancreatic cancer. / Shiomi, Miho; Mori, Shinichiro; Shinoto, Makoto; Nakayama, Yuko; Kamada, Tadashi; Yamada, Shigeru.

In: Radiotherapy and Oncology, Vol. 119, No. 2, 01.05.2016, p. 326-330.

Research output: Contribution to journalArticle

Shiomi, M, Mori, S, Shinoto, M, Nakayama, Y, Kamada, T & Yamada, S 2016, 'Comparison of carbon-ion passive and scanning irradiation for pancreatic cancer', Radiotherapy and Oncology, vol. 119, no. 2, pp. 326-330. https://doi.org/10.1016/j.radonc.2016.04.026
Shiomi, Miho ; Mori, Shinichiro ; Shinoto, Makoto ; Nakayama, Yuko ; Kamada, Tadashi ; Yamada, Shigeru. / Comparison of carbon-ion passive and scanning irradiation for pancreatic cancer. In: Radiotherapy and Oncology. 2016 ; Vol. 119, No. 2. pp. 326-330.
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