Comparison of cell nuclear DNA contents between intraepithelial and invasive components of oesophageal squamous cell carcinoma

Shinichi Tsutsui, Hiroyuki Kuwano, Masaki Mori, Hiroshi Matsuura, Keizo Sugimachi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Detailed cytophotometric analyses of cell nuclear DNA content were performed on 132 different areas from 24 oesophageal squamous cell carcinomas with an intraepithelial component. Measurements of DNA content were performed at the three different areas within each of the intraepithelial and invasive components. There were no differences in the overall incidence of DNA distribution patterns which were classified according to the degree of dispersion and the peak value on the DNA histogram between intraepithelial and invasive components, as well as the average of mean values of the DNA content. In 13 (54%) of 24 cases, there was a variation among the DNA distribution patterns obtained from three different areas of the intraepithelial components, whereas there was a variation in 4 (22%) of the 18 invasive components. In 11 of 13 intraepithelial components with a variation, the same DNA distribution pattern as seen in the invasive component was present. Provided that the DNA content remains stable, variations in intraepithelial components may reflect various tumour cell populations. These findings support the idea of a multicentric carcinogenesis of oesophageal carcinoma, and shed light on the mechanisms in which a single cell population is selected from various cell populations in the progression from an intraepithelial to an invasive lesion.

Original languageEnglish
Pages (from-to)630-638
Number of pages9
JournalEuropean Journal of Cancer and Clinical Oncology
Volume27
Issue number5
DOIs
Publication statusPublished - May 1991

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DNA
Population
Esophageal Squamous Cell Carcinoma
Carcinogenesis
Carcinoma
Incidence
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology

Cite this

Comparison of cell nuclear DNA contents between intraepithelial and invasive components of oesophageal squamous cell carcinoma. / Tsutsui, Shinichi; Kuwano, Hiroyuki; Mori, Masaki; Matsuura, Hiroshi; Sugimachi, Keizo.

In: European Journal of Cancer and Clinical Oncology, Vol. 27, No. 5, 05.1991, p. 630-638.

Research output: Contribution to journalArticle

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