TY - JOUR
T1 - Comparison of central effects of L-ornithine metabolites on the stress responses of neonatal chicks
AU - Kurauchi, I.
AU - Shigemi, K.
AU - Yamada, S.
AU - Aoki, M.
AU - Kawada, Y.
AU - Morishita, K.
AU - Denbow, D. M.
AU - Furuse, M.
PY - 2009
Y1 - 2009
N2 - Recently, we observed that central administration of L-arginine attenuated the stress responses of neonatal chicks by inducing a sedative and hypnotic effect. In addition, L-ornithine, which is produced from L-arginine in the brain, appeared to interact with L-arginine during a stress response. Several putative metabolites from L-ornithine, including L-citrullme and D-ornithine, were therefore investigated in the present study. The effects of intracerebroventricular injection of L-ornithine, L-citrulline and D-ornithine were compared in chicks under an isolation-induced stress. L-ornithine greatly attenuated the stress response and induced sedative and hypnotic effects. D-ornithine weakly attenuated the stress responses, while L-citrulline had no effect.
AB - Recently, we observed that central administration of L-arginine attenuated the stress responses of neonatal chicks by inducing a sedative and hypnotic effect. In addition, L-ornithine, which is produced from L-arginine in the brain, appeared to interact with L-arginine during a stress response. Several putative metabolites from L-ornithine, including L-citrullme and D-ornithine, were therefore investigated in the present study. The effects of intracerebroventricular injection of L-ornithine, L-citrulline and D-ornithine were compared in chicks under an isolation-induced stress. L-ornithine greatly attenuated the stress response and induced sedative and hypnotic effects. D-ornithine weakly attenuated the stress responses, while L-citrulline had no effect.
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M3 - Article
AN - SCOPUS:77951645860
VL - 8
SP - 2580
EP - 2584
JO - Journal of Animal and Veterinary Advances
JF - Journal of Animal and Veterinary Advances
SN - 1680-5593
IS - 12
ER -