Comparison of central effects of L-ornithine metabolites on the stress responses of neonatal chicks

I. Kurauchi, K. Shigemi, S. Yamada, M. Aoki, Y. Kawada, K. Morishita, D. M. Denbow, Mitsuhiro Furuse

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6 Citations (Scopus)

Abstract

Recently, we observed that central administration of L-arginine attenuated the stress responses of neonatal chicks by inducing a sedative and hypnotic effect. In addition, L-ornithine, which is produced from L-arginine in the brain, appeared to interact with L-arginine during a stress response. Several putative metabolites from L-ornithine, including L-citrullme and D-ornithine, were therefore investigated in the present study. The effects of intracerebroventricular injection of L-ornithine, L-citrulline and D-ornithine were compared in chicks under an isolation-induced stress. L-ornithine greatly attenuated the stress response and induced sedative and hypnotic effects. D-ornithine weakly attenuated the stress responses, while L-citrulline had no effect.

Original languageEnglish
Pages (from-to)2580-2584
Number of pages5
JournalJournal of Animal and Veterinary Advances
Volume8
Issue number12
Publication statusPublished - Dec 1 2009

All Science Journal Classification (ASJC) codes

  • Agronomy and Crop Science
  • veterinary(all)

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    Kurauchi, I., Shigemi, K., Yamada, S., Aoki, M., Kawada, Y., Morishita, K., Denbow, D. M., & Furuse, M. (2009). Comparison of central effects of L-ornithine metabolites on the stress responses of neonatal chicks. Journal of Animal and Veterinary Advances, 8(12), 2580-2584.