Comparison of Clinical Characteristics among Subtypes of Visual Symptoms in Patients with Transient Ischemic Attack: Analysis of the PROspective Multicenter registry to Identify Subsequent cardiovascular Events after TIA (PROMISE-TIA) Registry

PROMISE-TIA study Investigators

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Abstract

Background: A transient visual symptom (TVS) is a clinical manifestation of transient ischemic attack (TIA). The aim of this study was to investigate differences in clinical characteristics among subtypes of TVS using multicenter TIA registry data. Materials and Methods: Patients with TIA visiting within 7 days of onset were prospectively enrolled from 57 hospitals between June 2011 and December 2013. Clinical characteristics were compared between patients with 3 major subtypes of TVS (transient monocular blindness [TMB], homonymous lateral hemianopia [HLH], and diplopia). Results: Of 1365 patients, 106 (7.8%) had TVS, including 40 TMB (38%), 34 HLH (32%), 17 diplopia (16%), and 15 others/unknown (14%). Ninety-one patients with 1 of the 3 major subtypes of TVS were included. Symptoms persisted on arrival in 12 (13%) patients. Isolated TVS was significantly more common in TMB than in HLH and diplopia (88%, 62%, and 0%, respectively; P <.001). Duration of symptoms was shorter in patients with TMB than those with HLH (P =.004). The ABCD2 score was significantly lower in patients with TMB compared with those with HLH and diplopia (median 2 [interquartile range 2-3] versus 3 [2-4] and 4 [2-5], respectively; P =.005). Symptomatic extracranial internal carotid artery stenosis or occlusion was seen in 14 (16%) patients, and was more frequent in TMB than in HLH and diplopia (28%, 9%, and 0%, respectively; P =.015). Conclusions: TVS was an uncommon symptom in our TIA multicenter cohort. Some differences in clinical characteristics were found among subtypes of TVS.

Original languageEnglish
Pages (from-to)1711-1716
Number of pages6
JournalJournal of Stroke and Cerebrovascular Diseases
Volume27
Issue number6
DOIs
Publication statusPublished - Jun 2018

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Amaurosis Fugax
Transient Ischemic Attack
Hemianopsia
Registries
Diplopia
Carotid Stenosis

All Science Journal Classification (ASJC) codes

  • Surgery
  • Rehabilitation
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Cite this

@article{3ad33f0de95c4be69455c40224eb226d,
title = "Comparison of Clinical Characteristics among Subtypes of Visual Symptoms in Patients with Transient Ischemic Attack: Analysis of the PROspective Multicenter registry to Identify Subsequent cardiovascular Events after TIA (PROMISE-TIA) Registry",
abstract = "Background: A transient visual symptom (TVS) is a clinical manifestation of transient ischemic attack (TIA). The aim of this study was to investigate differences in clinical characteristics among subtypes of TVS using multicenter TIA registry data. Materials and Methods: Patients with TIA visiting within 7 days of onset were prospectively enrolled from 57 hospitals between June 2011 and December 2013. Clinical characteristics were compared between patients with 3 major subtypes of TVS (transient monocular blindness [TMB], homonymous lateral hemianopia [HLH], and diplopia). Results: Of 1365 patients, 106 (7.8{\%}) had TVS, including 40 TMB (38{\%}), 34 HLH (32{\%}), 17 diplopia (16{\%}), and 15 others/unknown (14{\%}). Ninety-one patients with 1 of the 3 major subtypes of TVS were included. Symptoms persisted on arrival in 12 (13{\%}) patients. Isolated TVS was significantly more common in TMB than in HLH and diplopia (88{\%}, 62{\%}, and 0{\%}, respectively; P <.001). Duration of symptoms was shorter in patients with TMB than those with HLH (P =.004). The ABCD2 score was significantly lower in patients with TMB compared with those with HLH and diplopia (median 2 [interquartile range 2-3] versus 3 [2-4] and 4 [2-5], respectively; P =.005). Symptomatic extracranial internal carotid artery stenosis or occlusion was seen in 14 (16{\%}) patients, and was more frequent in TMB than in HLH and diplopia (28{\%}, 9{\%}, and 0{\%}, respectively; P =.015). Conclusions: TVS was an uncommon symptom in our TIA multicenter cohort. Some differences in clinical characteristics were found among subtypes of TVS.",
author = "{PROMISE-TIA study Investigators} and Koji Tanaka and Toshiyuki Uehara and Kazumi Kimura and Yasushi Okada and Yasuhiro Hasegawa and Norio Tanahashi and Akifumi Suzuki and Jyoji Nakagawara and Kazumasa Arii and Shinji Nagahiro and Kuniaki Ogasawara and Shinichiro Uchiyama and Masayasu Matsumoto and Koji Iihara and Kazunori Toyoda and Kazuo Minematsu",
year = "2018",
month = "6",
doi = "10.1016/j.jstrokecerebrovasdis.2018.01.031",
language = "English",
volume = "27",
pages = "1711--1716",
journal = "Journal of Stroke and Cerebrovascular Diseases",
issn = "1052-3057",
publisher = "W.B. Saunders Ltd",
number = "6",

}

TY - JOUR

T1 - Comparison of Clinical Characteristics among Subtypes of Visual Symptoms in Patients with Transient Ischemic Attack

T2 - Analysis of the PROspective Multicenter registry to Identify Subsequent cardiovascular Events after TIA (PROMISE-TIA) Registry

AU - PROMISE-TIA study Investigators

AU - Tanaka, Koji

AU - Uehara, Toshiyuki

AU - Kimura, Kazumi

AU - Okada, Yasushi

AU - Hasegawa, Yasuhiro

AU - Tanahashi, Norio

AU - Suzuki, Akifumi

AU - Nakagawara, Jyoji

AU - Arii, Kazumasa

AU - Nagahiro, Shinji

AU - Ogasawara, Kuniaki

AU - Uchiyama, Shinichiro

AU - Matsumoto, Masayasu

AU - Iihara, Koji

AU - Toyoda, Kazunori

AU - Minematsu, Kazuo

PY - 2018/6

Y1 - 2018/6

N2 - Background: A transient visual symptom (TVS) is a clinical manifestation of transient ischemic attack (TIA). The aim of this study was to investigate differences in clinical characteristics among subtypes of TVS using multicenter TIA registry data. Materials and Methods: Patients with TIA visiting within 7 days of onset were prospectively enrolled from 57 hospitals between June 2011 and December 2013. Clinical characteristics were compared between patients with 3 major subtypes of TVS (transient monocular blindness [TMB], homonymous lateral hemianopia [HLH], and diplopia). Results: Of 1365 patients, 106 (7.8%) had TVS, including 40 TMB (38%), 34 HLH (32%), 17 diplopia (16%), and 15 others/unknown (14%). Ninety-one patients with 1 of the 3 major subtypes of TVS were included. Symptoms persisted on arrival in 12 (13%) patients. Isolated TVS was significantly more common in TMB than in HLH and diplopia (88%, 62%, and 0%, respectively; P <.001). Duration of symptoms was shorter in patients with TMB than those with HLH (P =.004). The ABCD2 score was significantly lower in patients with TMB compared with those with HLH and diplopia (median 2 [interquartile range 2-3] versus 3 [2-4] and 4 [2-5], respectively; P =.005). Symptomatic extracranial internal carotid artery stenosis or occlusion was seen in 14 (16%) patients, and was more frequent in TMB than in HLH and diplopia (28%, 9%, and 0%, respectively; P =.015). Conclusions: TVS was an uncommon symptom in our TIA multicenter cohort. Some differences in clinical characteristics were found among subtypes of TVS.

AB - Background: A transient visual symptom (TVS) is a clinical manifestation of transient ischemic attack (TIA). The aim of this study was to investigate differences in clinical characteristics among subtypes of TVS using multicenter TIA registry data. Materials and Methods: Patients with TIA visiting within 7 days of onset were prospectively enrolled from 57 hospitals between June 2011 and December 2013. Clinical characteristics were compared between patients with 3 major subtypes of TVS (transient monocular blindness [TMB], homonymous lateral hemianopia [HLH], and diplopia). Results: Of 1365 patients, 106 (7.8%) had TVS, including 40 TMB (38%), 34 HLH (32%), 17 diplopia (16%), and 15 others/unknown (14%). Ninety-one patients with 1 of the 3 major subtypes of TVS were included. Symptoms persisted on arrival in 12 (13%) patients. Isolated TVS was significantly more common in TMB than in HLH and diplopia (88%, 62%, and 0%, respectively; P <.001). Duration of symptoms was shorter in patients with TMB than those with HLH (P =.004). The ABCD2 score was significantly lower in patients with TMB compared with those with HLH and diplopia (median 2 [interquartile range 2-3] versus 3 [2-4] and 4 [2-5], respectively; P =.005). Symptomatic extracranial internal carotid artery stenosis or occlusion was seen in 14 (16%) patients, and was more frequent in TMB than in HLH and diplopia (28%, 9%, and 0%, respectively; P =.015). Conclusions: TVS was an uncommon symptom in our TIA multicenter cohort. Some differences in clinical characteristics were found among subtypes of TVS.

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U2 - 10.1016/j.jstrokecerebrovasdis.2018.01.031

DO - 10.1016/j.jstrokecerebrovasdis.2018.01.031

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AN - SCOPUS:85042915361

VL - 27

SP - 1711

EP - 1716

JO - Journal of Stroke and Cerebrovascular Diseases

JF - Journal of Stroke and Cerebrovascular Diseases

SN - 1052-3057

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