Comparison of Inflammation-Based Prognostic Scores Associated with the Prognostic Impact of Adenocarcinoma of Esophagogastric Junction and Upper Gastric Cancer

Kensuke Kudou, Yuichiro Nakashima, Yasuhiro Haruta, Sho Nambara, Yasuo Tsuda, Eiji Kusumoto, Koji Ando, Yasue Kimura, Kenkichi Hashimoto, Keiji Yoshinaga, Hiroshi Saeki, Eiji Oki, Yoshihisa Sakaguchi, Tetsuya Kusumoto, Koji Ikejiri, Mototsugu Shimokawa, Masaki Mori

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Abstract

Background: Several inflammation-based prognostic scores have a prognostic value in patients with various cancers. This study investigated the prognostic value of various inflammation-based prognostic scores in patients who underwent a surgery for adenocarcinoma of the esophagogastric junction (AEG) and upper gastric cancer (UGC). Methods: We reviewed data of 206 patients who underwent surgery for AEG and UGC. We calculated neutrophil–lymphocyte ratio (NLR), platelet–lymphocyte ratio (PLR), Glasgow Prognostic Score (GPS), modified GPS (mGPS), C-reactive protein (CRP)/albumin (Alb) ratio, prognostic index (PI), and prognostic nutritional index (PNI) and analyzed the relationship between these biomarkers and postoperative prognosis. Results: In multivariate analyses for overall survival, mGPS (P = 0.0337, hazard ratio [HR] = 5.211), PI (P = 0.0002, HR = 21.20), and PNI (P < 0.0001, HR = 6.907) were identified as independent predictive factors. A multivariate analysis for recurrence-free survival showed that only PI (P = 0.0006, HR = 11.89) and PNI (P = 0.0002, HR = 4.972) were independent predictive factors among the above-mentioned inflammation-based prognostic scores. Conclusions: In various inflammation-based prognostic scores, PI and PNI were more strongly associated with poor prognosis in patients who underwent surgery for AEG and UGC.

Original languageEnglish
Pages (from-to)2059-2067
Number of pages9
JournalAnnals of Surgical Oncology
Volume28
Issue number4
DOIs
Publication statusPublished - Apr 2021

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

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