Comparison of injuring effects of vesicant, irritant, and nonvesicant anticancer drugs on endothelial cells

Takaaki Yamada, Nobuaki Egashira, Maiko Imuta, Ayami Bando, Takahisa Yano, Mami Saito, Ryozo Oishi

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Anticancer drugs are classified as vesicant, irritant, and nonvesicant drugs on the basis of frequency of their vascular disorder. In this study, we compared the injuring effects of three typical anticancer drugs of each class on porcine aorta endothelial cells (PAECs). The concentration inducing 50% cell viability inhibition was lower in the order of vesicant, irritant, and nonvesicant drugs. These results suggest that injuring effects of anticancer drugs on PAECs may be relevant as an indicator of frequency of their vascular disorder, and that this experimental model may be useful for the study of vascular disorder.

Original languageEnglish
Pages (from-to)125-128
Number of pages4
JournalJournal of Pharmacological Sciences
Volume117
Issue number2
DOIs
Publication statusPublished - Oct 24 2011

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

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