TY - JOUR
T1 - Comparison of mammalian prolactin-releasing peptide and Carassius RFamide for feeding behavior and prolactin secretion in chicks
AU - Tachibana, Tetsuya
AU - Tsukada, Akira
AU - Fujimoto, Masaaki
AU - Takahashi, Hirokazu
AU - Ohkubo, Takeshi
AU - Boswell, Tim
AU - Furuse, Mitsuhiro
N1 - Funding Information:
This work was supported by a Grant-in-Aid for Young Scientists (No. 15780187) and a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science. We thank Nagoya University Radioisotope Center for use of facilities and Dr. A.F. Parlow and NIDDK National Hormone & Peptide Program for providing the chicken PRL and GH radioimmunoassay systems. We also thank Dr. K. Ukena, Hiroshima University, Japan, for his advices.
PY - 2005/12
Y1 - 2005/12
N2 - Prolactin-releasing peptide (PrRP) was named for its originally reported effects as a prolactin (PRL) secretagogue in mammals. Carassius RFamide (C-RFa) is an orthologous PRL secretagogue in fishes and a gene encoding a 20-amino acid peptide of identical sequence is present in the chicken. These facts suggest that C-RFa is a putative chicken PrRP. However, no information is available for the physiological effects of C-RFa in chickens. Therefore, in the present study, we compared the effect of intracerebroventricular (ICV) injection of C-RFa and mammalian PrRP (mPrRP) on feeding behavior and plasma PRL, growth hormone (GH), and corticosterone (CORT) concentrations. ICV injection of C-RFa did not affect feeding behavior of chicks while mPrRP was stimulatory. The injection of C-RFa also did not significantly affect plasma PRL, GH, and CORT concentrations. In contrast, ICV injection of mPrRP exerted similar effects to those reported in mammals by increasing plasma CORT and decreasing GH concentrations. Additionally, the peptide induced an unexpected inhibitory effect on plasma PRL concentrations. Overall, these data suggest that an as yet unidentified peptide that shares some functional similarities with mPrRP is present in birds, but that the physiological role of the avian 20-amino acid C-RFa peptide remains to be determined.
AB - Prolactin-releasing peptide (PrRP) was named for its originally reported effects as a prolactin (PRL) secretagogue in mammals. Carassius RFamide (C-RFa) is an orthologous PRL secretagogue in fishes and a gene encoding a 20-amino acid peptide of identical sequence is present in the chicken. These facts suggest that C-RFa is a putative chicken PrRP. However, no information is available for the physiological effects of C-RFa in chickens. Therefore, in the present study, we compared the effect of intracerebroventricular (ICV) injection of C-RFa and mammalian PrRP (mPrRP) on feeding behavior and plasma PRL, growth hormone (GH), and corticosterone (CORT) concentrations. ICV injection of C-RFa did not affect feeding behavior of chicks while mPrRP was stimulatory. The injection of C-RFa also did not significantly affect plasma PRL, GH, and CORT concentrations. In contrast, ICV injection of mPrRP exerted similar effects to those reported in mammals by increasing plasma CORT and decreasing GH concentrations. Additionally, the peptide induced an unexpected inhibitory effect on plasma PRL concentrations. Overall, these data suggest that an as yet unidentified peptide that shares some functional similarities with mPrRP is present in birds, but that the physiological role of the avian 20-amino acid C-RFa peptide remains to be determined.
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U2 - 10.1016/j.ygcen.2005.06.012
DO - 10.1016/j.ygcen.2005.06.012
M3 - Article
C2 - 16112673
AN - SCOPUS:27744449583
SN - 0016-6480
VL - 144
SP - 264
EP - 269
JO - General and Comparative Endocrinology
JF - General and Comparative Endocrinology
IS - 3
ER -