Comparison of matched-sibling donor BMT and unrelated donor BMT in children and adolescent with acquired severe aplastic anemia

H. Yagasaki, Y. Takahashi, A. Hama, K. Kudo, N. Nishio, H. Muramatsu, M. Tanaka, N. Yoshida, K. Matsumoto, N. Watanabe, K. Kato, K. Horibe, S. Kojima

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    40 Citations (Scopus)

    Abstract

    From January 1991 to March 2007, 61 children and adolescent with acquired severe aplastic anemia received BMT in our institutions. We retrospectively compared the outcome of 30 cases of matched-sibling donor BMT (MSD-BMT) and 31 cases of unrelated donor BMT (URD-BMT). We observed one graft failure among MSD-BMT recipients and three graft failures among URD-BMT recipients, respectively. No patients in the MSD-BMT group developed grades II-IV acute GVHD compared with 11 of 30 patients (37%) in the URD-BMT group (P<0.001). One of 30 MSD-BMT recipients (3%) developed chronic GVHD compared with 8 of 30 URD-BMT recipients (27%) (P=0.013). The incidence of EBV and CMV reactivation was 11 of 20 URD-BMT recipients and 23 of 30, respectively. One patient in the URD-BMT group died of a motor accident 5.5 years after BMT. Ten-year OS was 100% in MSDBMT recipients and 93.8% (95% CI, 81.9-100%) in URD-BMT recipients, respectively (P=0.252). Ten-year failure-free survival was 96.7% (95% CI, 90.2-100%) in the MSD-BMT group and 84.7% (95% CI, 70.2-99.2%) in the URD-BMT group, respectively (P=0.161).

    Original languageEnglish
    Pages (from-to)1508-1513
    Number of pages6
    JournalBone Marrow Transplantation
    Volume45
    Issue number10
    DOIs
    Publication statusPublished - Oct 2010

    All Science Journal Classification (ASJC) codes

    • Hematology
    • Transplantation

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