Comparison of MET-PET and FDG-PET for differentiation between benign lesions and malignant tumors of the lung

Masayuki Sasaki, Yasuo Kuwabara, Tsuyoshi Yoshida, Makoto Nakagawa, Hirofumi Koga, Kazutaka Hayashi, Kouichirou Kaneko, Tao Chen, Yuichi Ichiya, Kouji Masuda

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Abstract

Objective: We retrospectively assessed and compared the usefulness of 11C-methionine (MET)-PET with that of 18F-FDG-PET for the differentiation between benign lesions and malignant tumors of the lung. Methods: We examined 101 patients with a suspected lung tumor including 79 patients with primary lung cancer and 22 patients with benign lesions. One hundred and forty PET studies (46 studies with MET-PET and 94 studies with FDG-PET) were performed. Both MET-PET and FDG-PET were performed on 39 patients. The MET-PET was performed 15 minutes after the administration of 67-740 MBq of MET, and FDG-PET 45 minutes after the administration of 30-437 MBq of FDG. The results were then evaluated by the standardized uptake value (SUV). Results: The MET uptake in lung cancer was 3.69 ± 1.22 (n = 37) which was significantly higher than that in benign lesions 1.81 ± 1.04 (n = 9) (p < 0.001). The sensitivity, specificity and accuracy of MET-PET were 83.8%, 88.9% and 84.8%, respectively, when 2.66 of SUV was used as the cutoff value. The FDG uptake in lung cancer was 5.94 ± 2.89 (n = 75) and was also significantly larger than that in benign lesions 2.46 ± 1.01 (n = 19) (p < 0.001). The sensitivity, specificity and accuracy of FDG-PET were 81.3%, 78.9% and 80.9%, respectively (cutoff = 3.20). The MET uptake in the lesions correlated significantly with FDG uptake (r = 0.71, p < 0.001). According to an ROC analysis, the area under the curve for MET-PET (area = 0. 833) was higher than that for FDG-PET (area = 0.828), but the difference was not statistically significant. Furthermore, the combined use of MET-PET and FDG-PET did not improve the diagnostic ability. Conclusions: In conclusion, both MET-PET and FDG-PET were considered to be equally useful for the differential diagnosis of lung tumors. Furthermore, MET uptake in lung lesions was found to correlate significantly with FDG uptake.

Original languageEnglish
Pages (from-to)425-431
Number of pages7
JournalAnnals of Nuclear Medicine
Volume15
Issue number5
DOIs
Publication statusPublished - Jan 1 2001

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Methionine
Lung
Neoplasms
Lung Neoplasms
Sensitivity and Specificity
Fluorodeoxyglucose F18
ROC Curve
Area Under Curve
Differential Diagnosis

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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Comparison of MET-PET and FDG-PET for differentiation between benign lesions and malignant tumors of the lung. / Sasaki, Masayuki; Kuwabara, Yasuo; Yoshida, Tsuyoshi; Nakagawa, Makoto; Koga, Hirofumi; Hayashi, Kazutaka; Kaneko, Kouichirou; Chen, Tao; Ichiya, Yuichi; Masuda, Kouji.

In: Annals of Nuclear Medicine, Vol. 15, No. 5, 01.01.2001, p. 425-431.

Research output: Contribution to journalArticle

Sasaki, M, Kuwabara, Y, Yoshida, T, Nakagawa, M, Koga, H, Hayashi, K, Kaneko, K, Chen, T, Ichiya, Y & Masuda, K 2001, 'Comparison of MET-PET and FDG-PET for differentiation between benign lesions and malignant tumors of the lung', Annals of Nuclear Medicine, vol. 15, no. 5, pp. 425-431. https://doi.org/10.1007/BF02988346
Sasaki, Masayuki ; Kuwabara, Yasuo ; Yoshida, Tsuyoshi ; Nakagawa, Makoto ; Koga, Hirofumi ; Hayashi, Kazutaka ; Kaneko, Kouichirou ; Chen, Tao ; Ichiya, Yuichi ; Masuda, Kouji. / Comparison of MET-PET and FDG-PET for differentiation between benign lesions and malignant tumors of the lung. In: Annals of Nuclear Medicine. 2001 ; Vol. 15, No. 5. pp. 425-431.
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abstract = "Objective: We retrospectively assessed and compared the usefulness of 11C-methionine (MET)-PET with that of 18F-FDG-PET for the differentiation between benign lesions and malignant tumors of the lung. Methods: We examined 101 patients with a suspected lung tumor including 79 patients with primary lung cancer and 22 patients with benign lesions. One hundred and forty PET studies (46 studies with MET-PET and 94 studies with FDG-PET) were performed. Both MET-PET and FDG-PET were performed on 39 patients. The MET-PET was performed 15 minutes after the administration of 67-740 MBq of MET, and FDG-PET 45 minutes after the administration of 30-437 MBq of FDG. The results were then evaluated by the standardized uptake value (SUV). Results: The MET uptake in lung cancer was 3.69 ± 1.22 (n = 37) which was significantly higher than that in benign lesions 1.81 ± 1.04 (n = 9) (p < 0.001). The sensitivity, specificity and accuracy of MET-PET were 83.8{\%}, 88.9{\%} and 84.8{\%}, respectively, when 2.66 of SUV was used as the cutoff value. The FDG uptake in lung cancer was 5.94 ± 2.89 (n = 75) and was also significantly larger than that in benign lesions 2.46 ± 1.01 (n = 19) (p < 0.001). The sensitivity, specificity and accuracy of FDG-PET were 81.3{\%}, 78.9{\%} and 80.9{\%}, respectively (cutoff = 3.20). The MET uptake in the lesions correlated significantly with FDG uptake (r = 0.71, p < 0.001). According to an ROC analysis, the area under the curve for MET-PET (area = 0. 833) was higher than that for FDG-PET (area = 0.828), but the difference was not statistically significant. Furthermore, the combined use of MET-PET and FDG-PET did not improve the diagnostic ability. Conclusions: In conclusion, both MET-PET and FDG-PET were considered to be equally useful for the differential diagnosis of lung tumors. Furthermore, MET uptake in lung lesions was found to correlate significantly with FDG uptake.",
author = "Masayuki Sasaki and Yasuo Kuwabara and Tsuyoshi Yoshida and Makoto Nakagawa and Hirofumi Koga and Kazutaka Hayashi and Kouichirou Kaneko and Tao Chen and Yuichi Ichiya and Kouji Masuda",
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T1 - Comparison of MET-PET and FDG-PET for differentiation between benign lesions and malignant tumors of the lung

AU - Sasaki, Masayuki

AU - Kuwabara, Yasuo

AU - Yoshida, Tsuyoshi

AU - Nakagawa, Makoto

AU - Koga, Hirofumi

AU - Hayashi, Kazutaka

AU - Kaneko, Kouichirou

AU - Chen, Tao

AU - Ichiya, Yuichi

AU - Masuda, Kouji

PY - 2001/1/1

Y1 - 2001/1/1

N2 - Objective: We retrospectively assessed and compared the usefulness of 11C-methionine (MET)-PET with that of 18F-FDG-PET for the differentiation between benign lesions and malignant tumors of the lung. Methods: We examined 101 patients with a suspected lung tumor including 79 patients with primary lung cancer and 22 patients with benign lesions. One hundred and forty PET studies (46 studies with MET-PET and 94 studies with FDG-PET) were performed. Both MET-PET and FDG-PET were performed on 39 patients. The MET-PET was performed 15 minutes after the administration of 67-740 MBq of MET, and FDG-PET 45 minutes after the administration of 30-437 MBq of FDG. The results were then evaluated by the standardized uptake value (SUV). Results: The MET uptake in lung cancer was 3.69 ± 1.22 (n = 37) which was significantly higher than that in benign lesions 1.81 ± 1.04 (n = 9) (p < 0.001). The sensitivity, specificity and accuracy of MET-PET were 83.8%, 88.9% and 84.8%, respectively, when 2.66 of SUV was used as the cutoff value. The FDG uptake in lung cancer was 5.94 ± 2.89 (n = 75) and was also significantly larger than that in benign lesions 2.46 ± 1.01 (n = 19) (p < 0.001). The sensitivity, specificity and accuracy of FDG-PET were 81.3%, 78.9% and 80.9%, respectively (cutoff = 3.20). The MET uptake in the lesions correlated significantly with FDG uptake (r = 0.71, p < 0.001). According to an ROC analysis, the area under the curve for MET-PET (area = 0. 833) was higher than that for FDG-PET (area = 0.828), but the difference was not statistically significant. Furthermore, the combined use of MET-PET and FDG-PET did not improve the diagnostic ability. Conclusions: In conclusion, both MET-PET and FDG-PET were considered to be equally useful for the differential diagnosis of lung tumors. Furthermore, MET uptake in lung lesions was found to correlate significantly with FDG uptake.

AB - Objective: We retrospectively assessed and compared the usefulness of 11C-methionine (MET)-PET with that of 18F-FDG-PET for the differentiation between benign lesions and malignant tumors of the lung. Methods: We examined 101 patients with a suspected lung tumor including 79 patients with primary lung cancer and 22 patients with benign lesions. One hundred and forty PET studies (46 studies with MET-PET and 94 studies with FDG-PET) were performed. Both MET-PET and FDG-PET were performed on 39 patients. The MET-PET was performed 15 minutes after the administration of 67-740 MBq of MET, and FDG-PET 45 minutes after the administration of 30-437 MBq of FDG. The results were then evaluated by the standardized uptake value (SUV). Results: The MET uptake in lung cancer was 3.69 ± 1.22 (n = 37) which was significantly higher than that in benign lesions 1.81 ± 1.04 (n = 9) (p < 0.001). The sensitivity, specificity and accuracy of MET-PET were 83.8%, 88.9% and 84.8%, respectively, when 2.66 of SUV was used as the cutoff value. The FDG uptake in lung cancer was 5.94 ± 2.89 (n = 75) and was also significantly larger than that in benign lesions 2.46 ± 1.01 (n = 19) (p < 0.001). The sensitivity, specificity and accuracy of FDG-PET were 81.3%, 78.9% and 80.9%, respectively (cutoff = 3.20). The MET uptake in the lesions correlated significantly with FDG uptake (r = 0.71, p < 0.001). According to an ROC analysis, the area under the curve for MET-PET (area = 0. 833) was higher than that for FDG-PET (area = 0.828), but the difference was not statistically significant. Furthermore, the combined use of MET-PET and FDG-PET did not improve the diagnostic ability. Conclusions: In conclusion, both MET-PET and FDG-PET were considered to be equally useful for the differential diagnosis of lung tumors. Furthermore, MET uptake in lung lesions was found to correlate significantly with FDG uptake.

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