Comparison of p53 and CD44 variant 6 expression between paired primary and recurrent ovarian cancer: An immunohistochemical analysis

Toshiharu Kamura, Kunihiro Sakai, Tsunehisa Kaku, Hiroaki Kobayashi, Masamune Mitsumoto, Masazumi Tsuneyoshi, Hitoo Nakano

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Abstract

Progression of malignant potential in ovarian cancer was investigated by comparing recurrent tumor with their primary tumor counterparts in terms of p53 and CD44 variant 6 (CD44v6) expression. Forty-three paired primary and recurrent tumors were immunohistochemically evaluated for expression of p53 and CD44v6. A paired analysis revealed that p53 and CD44v6 expression were significantly greater in recurrent tumors than those in the primary counterparts with statistical significance, respectively (P=0.0055 and 0.0071; Wilcoxon signed-rank test). No relationship between these two proteins was found. These results suggested that recurrent ovarian cancer may possibly express a stronger malignant potential in comparison to the primary tumor.

Original languageEnglish
Pages (from-to)97-101
Number of pages5
JournalOncology reports
Volume6
Issue number1
Publication statusPublished - Dec 1 1999

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Ovarian Neoplasms
Neoplasms
Nonparametric Statistics
Proteins

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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Kamura, T., Sakai, K., Kaku, T., Kobayashi, H., Mitsumoto, M., Tsuneyoshi, M., & Nakano, H. (1999). Comparison of p53 and CD44 variant 6 expression between paired primary and recurrent ovarian cancer: An immunohistochemical analysis. Oncology reports, 6(1), 97-101.

Comparison of p53 and CD44 variant 6 expression between paired primary and recurrent ovarian cancer : An immunohistochemical analysis. / Kamura, Toshiharu; Sakai, Kunihiro; Kaku, Tsunehisa; Kobayashi, Hiroaki; Mitsumoto, Masamune; Tsuneyoshi, Masazumi; Nakano, Hitoo.

In: Oncology reports, Vol. 6, No. 1, 01.12.1999, p. 97-101.

Research output: Contribution to journalArticle

Kamura, T, Sakai, K, Kaku, T, Kobayashi, H, Mitsumoto, M, Tsuneyoshi, M & Nakano, H 1999, 'Comparison of p53 and CD44 variant 6 expression between paired primary and recurrent ovarian cancer: An immunohistochemical analysis', Oncology reports, vol. 6, no. 1, pp. 97-101.
Kamura T, Sakai K, Kaku T, Kobayashi H, Mitsumoto M, Tsuneyoshi M et al. Comparison of p53 and CD44 variant 6 expression between paired primary and recurrent ovarian cancer: An immunohistochemical analysis. Oncology reports. 1999 Dec 1;6(1):97-101.
Kamura, Toshiharu ; Sakai, Kunihiro ; Kaku, Tsunehisa ; Kobayashi, Hiroaki ; Mitsumoto, Masamune ; Tsuneyoshi, Masazumi ; Nakano, Hitoo. / Comparison of p53 and CD44 variant 6 expression between paired primary and recurrent ovarian cancer : An immunohistochemical analysis. In: Oncology reports. 1999 ; Vol. 6, No. 1. pp. 97-101.
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