Comparison of p53 and CD44 variant 6 expression between paired primary and recurrent ovarian cancer: An immunohistochemical analysis

Toshiharu Kamura, Kunihiro Sakai, Tsunehisa Kaku, Hiroaki Kobayashi, Masamune Mitsumoto, Masazumi Tsuneyoshi, Hitoo Nakano

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Progression of malignant potential in ovarian cancer was investigated by comparing recurrent tumor with their primary tumor counterparts in terms of p53 and CD44 variant 6 (CD44v6) expression. Forty-three paired primary and recurrent tumors were immunohistochemically evaluated for expression of p53 and CD44v6. A paired analysis revealed that p53 and CD44v6 expression were significantly greater in recurrent tumors than those in the primary counterparts with statistical significance, respectively (P=0.0055 and 0.0071; Wilcoxon signed-rank test). No relationship between these two proteins was found. These results suggested that recurrent ovarian cancer may possibly express a stronger malignant potential in comparison to the primary tumor.

Original languageEnglish
Pages (from-to)97-101
Number of pages5
JournalOncology reports
Volume6
Issue number1
DOIs
Publication statusPublished - Jan 1 1999

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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