Comparison of prognostic values of daytime and night-time systolic blood pressures on renal outcomes in patients with Chronic kidney disease

Eisuke Katafuchi, Masaru Nakayama, Shigeru Tanaka, Teppei Sakoh, Ryota Yoshitomi, Akiko Fukui, Makiko Seki, Yusuke Nakamata, Mitsuhiro Tominaga, Kazuhiko Tsuruya, Takanari Kitazono

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Differences in the predictive value of daytime systolic blood pressure (SBP) and night-time SBP by ambulatory blood pressure monitoring on renal outcomes have not been fully investigated in chronic kidney disease (CKD) patients. This study compared the prognostic value between daytime and night-time SBP on renal outcomes in CKD. Methods and Results: This prospective observational study included 421 patients. The composite renal endpoint was endstage renal disease (ESRD) or death. Cox models were used to determine associations of daytime and night-time SBP with renal outcomes. There were 150 renal events (ESRD, 130; death, 20). Multivariable Cox analyses demonstrated that hazard ratios (HRs) [95% confidence interval (CI)] for composite renal outcomes of every 10-mmHg increase in daytime and night-time SBP levels were 1.13 (1.02-1.26) (P=0.02) and 1.15 (1.05-1.27) (P<0.01), respectively. In addition, compared with the 1st daytime or night-time SBP quartile, HRs (95% CI) for outcomes in the 2nd, 3rd, and 4th quartiles were: daytime SBP, 1.25 (0.70-2.25), 1.09 (0.61-1.94), and 1.58 (0.88-2.85; P=0.13) (P for trend=0.16); night-time SBP, 1.09 (0.61-1.96), 1.31 (0.76-2.28), and 1.82 (1.00-3.30; P=0.049) (P for trend=0.03), respectively. Conclusions: Night-time SBP appeared superior to daytime SBP for predicting renal outcomes in this population of patients.

Original languageEnglish
Pages (from-to)1454-1462
Number of pages9
JournalCirculation Journal
Volume81
Issue number10
DOIs
Publication statusPublished - Jan 1 2017

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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