Comparison of propofol LCT and propofol MCT/LCT regarding the injection pain at different sites and the memory

Akiko Ozawa, Masako Isono, Tetsuo Ueno, Yasuharu Kosaka, Takaaki Nakano, Mihoko Inamura, Akifumi Kanai, Hirotsugu Okamoto, Sumio Hoka, Susumu Nomiyama

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Incidence and intensity of pain on intravenous injection of propofol LCT were compared with those of propofol MCT/LCT. Methods: Eighty adult patients scheduled to receive general anesthesia were divided into two groups, propofol LCT (Group L, AstraZeneca) and propofol MCT/LCT (Group M, Maruishi Pharmaceutical). The peripheral vein was inserted with an 18 gauge intravenous catheter at the dorsal hand, the wrist, or the anterior brachial region. Propofol 2.0 mg · kg-1 was injected at the speed of 5 mg · sec-1. Noninvasive arterial blood pressure, heart rate, a BIS value and a degree of pain were measured. We used x2 analysis and Wilcoxon t-test for statistical evaluation. Results: There was a significantly larger incidence of injection pain in the Group L than the Group M (70% vs. 30%). The pain at the brachial region was significantly less as compared with the wrist or the dorsal hand in both groups. The ratio of patients having the memory of pain on the next day to those complaing the injection pain was 50% in the Group L and 36% in the Group M. There were no significant differences between the two groups in changes in BIS values and doses of propofol necessary for the loss of consciousness. Conclusions: The results suggest that propofol MCT/LCT elicits less pain on injection than propofol LCT. The injection pain is less at the brachial region than the wrist or the hand. Amnesia of pain may be obtained both with propofol MCT/LCT and propofol LCT.

Original languageEnglish
Pages (from-to)1241-1246
Number of pages6
JournalJapanese Journal of Anesthesiology
Volume54
Issue number11
Publication statusPublished - Nov 2005
Externally publishedYes

Fingerprint

Propofol
Pain
Injections
Wrist
Arm
Hand
Amnesia
Unconsciousness
Incidence
Intravenous Injections
General Anesthesia
Veins
Arterial Pressure
Catheters
Heart Rate

All Science Journal Classification (ASJC) codes

  • Anesthesiology and Pain Medicine

Cite this

Ozawa, A., Isono, M., Ueno, T., Kosaka, Y., Nakano, T., Inamura, M., ... Nomiyama, S. (2005). Comparison of propofol LCT and propofol MCT/LCT regarding the injection pain at different sites and the memory. Japanese Journal of Anesthesiology, 54(11), 1241-1246.

Comparison of propofol LCT and propofol MCT/LCT regarding the injection pain at different sites and the memory. / Ozawa, Akiko; Isono, Masako; Ueno, Tetsuo; Kosaka, Yasuharu; Nakano, Takaaki; Inamura, Mihoko; Kanai, Akifumi; Okamoto, Hirotsugu; Hoka, Sumio; Nomiyama, Susumu.

In: Japanese Journal of Anesthesiology, Vol. 54, No. 11, 11.2005, p. 1241-1246.

Research output: Contribution to journalArticle

Ozawa, A, Isono, M, Ueno, T, Kosaka, Y, Nakano, T, Inamura, M, Kanai, A, Okamoto, H, Hoka, S & Nomiyama, S 2005, 'Comparison of propofol LCT and propofol MCT/LCT regarding the injection pain at different sites and the memory', Japanese Journal of Anesthesiology, vol. 54, no. 11, pp. 1241-1246.
Ozawa, Akiko ; Isono, Masako ; Ueno, Tetsuo ; Kosaka, Yasuharu ; Nakano, Takaaki ; Inamura, Mihoko ; Kanai, Akifumi ; Okamoto, Hirotsugu ; Hoka, Sumio ; Nomiyama, Susumu. / Comparison of propofol LCT and propofol MCT/LCT regarding the injection pain at different sites and the memory. In: Japanese Journal of Anesthesiology. 2005 ; Vol. 54, No. 11. pp. 1241-1246.
@article{6cebb9ebc9074137a7c84af7f5844f49,
title = "Comparison of propofol LCT and propofol MCT/LCT regarding the injection pain at different sites and the memory",
abstract = "Background: Incidence and intensity of pain on intravenous injection of propofol LCT were compared with those of propofol MCT/LCT. Methods: Eighty adult patients scheduled to receive general anesthesia were divided into two groups, propofol LCT (Group L, AstraZeneca) and propofol MCT/LCT (Group M, Maruishi Pharmaceutical). The peripheral vein was inserted with an 18 gauge intravenous catheter at the dorsal hand, the wrist, or the anterior brachial region. Propofol 2.0 mg · kg-1 was injected at the speed of 5 mg · sec-1. Noninvasive arterial blood pressure, heart rate, a BIS value and a degree of pain were measured. We used x2 analysis and Wilcoxon t-test for statistical evaluation. Results: There was a significantly larger incidence of injection pain in the Group L than the Group M (70{\%} vs. 30{\%}). The pain at the brachial region was significantly less as compared with the wrist or the dorsal hand in both groups. The ratio of patients having the memory of pain on the next day to those complaing the injection pain was 50{\%} in the Group L and 36{\%} in the Group M. There were no significant differences between the two groups in changes in BIS values and doses of propofol necessary for the loss of consciousness. Conclusions: The results suggest that propofol MCT/LCT elicits less pain on injection than propofol LCT. The injection pain is less at the brachial region than the wrist or the hand. Amnesia of pain may be obtained both with propofol MCT/LCT and propofol LCT.",
author = "Akiko Ozawa and Masako Isono and Tetsuo Ueno and Yasuharu Kosaka and Takaaki Nakano and Mihoko Inamura and Akifumi Kanai and Hirotsugu Okamoto and Sumio Hoka and Susumu Nomiyama",
year = "2005",
month = "11",
language = "English",
volume = "54",
pages = "1241--1246",
journal = "Japanese Journal of Anesthesiology",
issn = "0021-4892",
publisher = "Kokuseido Publishing Co. Ltd",
number = "11",

}

TY - JOUR

T1 - Comparison of propofol LCT and propofol MCT/LCT regarding the injection pain at different sites and the memory

AU - Ozawa, Akiko

AU - Isono, Masako

AU - Ueno, Tetsuo

AU - Kosaka, Yasuharu

AU - Nakano, Takaaki

AU - Inamura, Mihoko

AU - Kanai, Akifumi

AU - Okamoto, Hirotsugu

AU - Hoka, Sumio

AU - Nomiyama, Susumu

PY - 2005/11

Y1 - 2005/11

N2 - Background: Incidence and intensity of pain on intravenous injection of propofol LCT were compared with those of propofol MCT/LCT. Methods: Eighty adult patients scheduled to receive general anesthesia were divided into two groups, propofol LCT (Group L, AstraZeneca) and propofol MCT/LCT (Group M, Maruishi Pharmaceutical). The peripheral vein was inserted with an 18 gauge intravenous catheter at the dorsal hand, the wrist, or the anterior brachial region. Propofol 2.0 mg · kg-1 was injected at the speed of 5 mg · sec-1. Noninvasive arterial blood pressure, heart rate, a BIS value and a degree of pain were measured. We used x2 analysis and Wilcoxon t-test for statistical evaluation. Results: There was a significantly larger incidence of injection pain in the Group L than the Group M (70% vs. 30%). The pain at the brachial region was significantly less as compared with the wrist or the dorsal hand in both groups. The ratio of patients having the memory of pain on the next day to those complaing the injection pain was 50% in the Group L and 36% in the Group M. There were no significant differences between the two groups in changes in BIS values and doses of propofol necessary for the loss of consciousness. Conclusions: The results suggest that propofol MCT/LCT elicits less pain on injection than propofol LCT. The injection pain is less at the brachial region than the wrist or the hand. Amnesia of pain may be obtained both with propofol MCT/LCT and propofol LCT.

AB - Background: Incidence and intensity of pain on intravenous injection of propofol LCT were compared with those of propofol MCT/LCT. Methods: Eighty adult patients scheduled to receive general anesthesia were divided into two groups, propofol LCT (Group L, AstraZeneca) and propofol MCT/LCT (Group M, Maruishi Pharmaceutical). The peripheral vein was inserted with an 18 gauge intravenous catheter at the dorsal hand, the wrist, or the anterior brachial region. Propofol 2.0 mg · kg-1 was injected at the speed of 5 mg · sec-1. Noninvasive arterial blood pressure, heart rate, a BIS value and a degree of pain were measured. We used x2 analysis and Wilcoxon t-test for statistical evaluation. Results: There was a significantly larger incidence of injection pain in the Group L than the Group M (70% vs. 30%). The pain at the brachial region was significantly less as compared with the wrist or the dorsal hand in both groups. The ratio of patients having the memory of pain on the next day to those complaing the injection pain was 50% in the Group L and 36% in the Group M. There were no significant differences between the two groups in changes in BIS values and doses of propofol necessary for the loss of consciousness. Conclusions: The results suggest that propofol MCT/LCT elicits less pain on injection than propofol LCT. The injection pain is less at the brachial region than the wrist or the hand. Amnesia of pain may be obtained both with propofol MCT/LCT and propofol LCT.

UR - http://www.scopus.com/inward/record.url?scp=28244470310&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=28244470310&partnerID=8YFLogxK

M3 - Article

VL - 54

SP - 1241

EP - 1246

JO - Japanese Journal of Anesthesiology

JF - Japanese Journal of Anesthesiology

SN - 0021-4892

IS - 11

ER -