Comparison of ready-made and self-setting alginate membranes used as a barrier membrane for guided bone regeneration

Yoshiya Ueyama, Takahiro Koyama, Kunio Ishikawa, Takamitsu Mano, Yukio Ogawa, Hitoshi Nagatsuka, Kazuomi Suzuki

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

In order to understand the requirements of guided bone regeneration (GBR) involving alginate base self-setting barrier membranes, GBR was performed in the case of bicortical bone defects formed at the tibiae of experimental animals employing self-setting and ready-made alginate membranes. Connective tissue ingress into the bone defects at the skin side of the tibia was observed when GBR was generated utilizing ready-made alginate membrane. In contrast, bone defects were reconstructed with bone tissue when GBR was generated with self-setting alginate membrane formed from aqueous 3% sodium alginate and 3% CaCl2 solutions. The unreacted aqueous sodium alginate solution inherent to self-setting alginate membrane did not inhibit bone tissue regeneration. Rather, callus bone was formed using sodium alginate as the nucleus. However, when GBR was effected with self-setting alginate membrane formed from aqueous 10% CaCl2 solution, membrane was too thick and thus regeneration of bone tissue in the bone cavity was prevented. Therefore, we concluded that self-setting alginate membrane is very useful as a barrier membrane for GBR upon appropriate adjustment of conditions with respect to preparation of alginate membrane.

Original languageEnglish
Pages (from-to)281-288
Number of pages8
JournalJournal of Materials Science: Materials in Medicine
Volume17
Issue number3
DOIs
Publication statusPublished - Mar 1 2006

Fingerprint

Bone Regeneration
Alginate
Bone
Membranes
Bone and Bones
Sodium alginate
Tibia
Tissue
alginic acid
Defects
Bony Callus
Tissue regeneration
Connective Tissue
Regeneration

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

Cite this

Comparison of ready-made and self-setting alginate membranes used as a barrier membrane for guided bone regeneration. / Ueyama, Yoshiya; Koyama, Takahiro; Ishikawa, Kunio; Mano, Takamitsu; Ogawa, Yukio; Nagatsuka, Hitoshi; Suzuki, Kazuomi.

In: Journal of Materials Science: Materials in Medicine, Vol. 17, No. 3, 01.03.2006, p. 281-288.

Research output: Contribution to journalArticle

Ueyama, Yoshiya ; Koyama, Takahiro ; Ishikawa, Kunio ; Mano, Takamitsu ; Ogawa, Yukio ; Nagatsuka, Hitoshi ; Suzuki, Kazuomi. / Comparison of ready-made and self-setting alginate membranes used as a barrier membrane for guided bone regeneration. In: Journal of Materials Science: Materials in Medicine. 2006 ; Vol. 17, No. 3. pp. 281-288.
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